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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Triiodothyronine differentially modulates the LH and FSH synthesis and secretion in male rats

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Author(s):
Romano, Renata Marino [1] ; Bargi-Souza, Paula [1] ; Brunetto, Erika Lia [1] ; Goulart-Silva, Francemilson [1] ; Salgado, Renato M. [2] ; Tenorio Zorn, Telma Maria [2] ; Nunes, Maria Tereza [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Prof Lineu Prestes 1524, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ENDOCRINE; v. 59, n. 1, p. 191-202, JAN 2018.
Web of Science Citations: 2
Abstract

Hypothyroidism and thyrotoxicosis produce adverse effects in male reproduction by unknown mechanisms. We investigated whether triiodothyronine (T3) modulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) synthesis/secretion, by inducing different thyroid states. In hypothyroidism, the content of Lhb and Fshb mRNAs was increased, while their association to ribosomes and the protein content were reduced and the serum LH and FSH concentrations were augmented and decreased, respectively. Thyrotoxicosis reduced Lhb mRNA and LH serum concentration, and increased Lhb mRNA translational rate. The Fshb mRNA content and its association to ribosomes were also increased, whereas FSH serum concentrations were comparable to euthyroid levels. Acute T3 treatment decreased the total content of Lhb and Fshb mRNAs, and increased their association to ribosomes, as well as the LHB and FSHB contents in secretory granules. This study shows that T3 acts on gonadotrophs, resulting in direct effects on LH and FSH synthesis/secretion of male rats, suggesting that some reproductive disorders observed in men may be associated with thyroid hormone imbalances. (AU)

FAPESP's process: 09/17822-8 - Repercussions of the thyroid hormone treatment on the molecular markers of the gonadal function
Grantee:Maria Tereza Nunes
Support Opportunities: Regular Research Grants
FAPESP's process: 13/05629-4 - Genomic vs nongenomic actions of thyroid hormones: changes of paradigms, physiological implications and therapeutical perspectives
Grantee:Maria Tereza Nunes
Support Opportunities: Research Projects - Thematic Grants