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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Staphylococcus aureus enterotoxins modulate IL-22-secreting cells in adults with atopic dermatitis

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Autor(es):
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Orfali, Raquel Leao [1] ; da Silva Oliveira, Luanda Mara [1] ; de Lima, Josenilson Feitosa [1] ; de Carvalho, Gabriel Costa [1] ; Leuzzi Ramos, Yasmim Alefe [1] ; Pereira, Natalli Zanete [1] ; Pereira, Naiura Vieira [1] ; Zaniboni, Mariana Colombini [1] ; Sotto, Mirian Nacagami [1] ; da Silva Duarte, Alberto Jose [1] ; Sato, Maria Notomi [1] ; Aoki, Valeria [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Med Sch, Dept Dermatol, Lab Dermatol & Immunodeficiencies LIM 56, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 8, APR 27 2018.
Citações Web of Science: 5
Resumo

Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4(+/)CD8(+)T cells expressing IL-22 in AD skin. Our study showed inhibition of the staphylococcal enterotoxins A and B (SEA and SEB) response by Th22 (CD4(+)IL22(+)IL-17A(-)IFN-gamma(-)) cells in AD patients. In contrast, Tc22 (CD8(+)IL-22(+)IL-17A(-)IFN-gamma(-)) cells were less susceptible to the inhibitory effects of staphylococcal enterotoxins and exhibited an enhanced response to the bacterial stimuli. In AD skin, we detected increased IL-22 transcript expression and T lymphocytes expressing IL-22. Together, our results provide two major findings in response to staphylococcal enterotoxins in adults with AD: dysfunctional CD4(+)IL-22 secreting T cells and increased Tc22 cells. Our hypothesis reinforces the relevance of CD8 T cells modulated by staphylococcal enterotoxins as a potential source of IL-22 in adults with AD, which is relevant for the maintenance of immunological imbalance. (AU)

Processo FAPESP: 16/24161-1 - Caracterização proteômica de exossomas do plasma e de fibroblastos dérmicos na dermatite atópica do adulto
Beneficiário:Raquel Leão Orfali
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/25645-7 - Avaliação fenotípica e funcional de células dendríticas inflamatórias e de células T na dermatite atópica do adulto
Beneficiário:Valeria Aoki
Linha de fomento: Auxílio à Pesquisa - Regular