| Texto completo | |
| Autor(es): Mostrar menos - |
Orfali, Raquel Leao
[1]
;
da Silva Oliveira, Luanda Mara
[1]
;
de Lima, Josenilson Feitosa
[1]
;
de Carvalho, Gabriel Costa
[1]
;
Leuzzi Ramos, Yasmim Alefe
[1]
;
Pereira, Natalli Zanete
[1]
;
Pereira, Naiura Vieira
[1]
;
Zaniboni, Mariana Colombini
[1]
;
Sotto, Mirian Nacagami
[1]
;
da Silva Duarte, Alberto Jose
[1]
;
Sato, Maria Notomi
[1]
;
Aoki, Valeria
[1]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Med Sch, Dept Dermatol, Lab Dermatol & Immunodeficiencies LIM 56, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 8, APR 27 2018. |
| Citações Web of Science: | 5 |
| Resumo | |
Atopic dermatitis (AD) is a chronic inflammatory immune-mediated skin disease characterized by skin colonization by Staphylococcus aureus. Interleukin (IL)-22, in cooperation with IL-17, triggers antimicrobial peptide elaboration and enhances certain immunological responses. In AD, IL-22 is related to epidermal hyperplasia, keratinocyte apoptosis, and inhibition of antimicrobial peptide (AMP) production. We aimed to evaluate the impact of staphylococcal enterotoxins on the Tc22/Th22 induction in the peripheral blood of AD patients and on CD4(+/)CD8(+)T cells expressing IL-22 in AD skin. Our study showed inhibition of the staphylococcal enterotoxins A and B (SEA and SEB) response by Th22 (CD4(+)IL22(+)IL-17A(-)IFN-gamma(-)) cells in AD patients. In contrast, Tc22 (CD8(+)IL-22(+)IL-17A(-)IFN-gamma(-)) cells were less susceptible to the inhibitory effects of staphylococcal enterotoxins and exhibited an enhanced response to the bacterial stimuli. In AD skin, we detected increased IL-22 transcript expression and T lymphocytes expressing IL-22. Together, our results provide two major findings in response to staphylococcal enterotoxins in adults with AD: dysfunctional CD4(+)IL-22 secreting T cells and increased Tc22 cells. Our hypothesis reinforces the relevance of CD8 T cells modulated by staphylococcal enterotoxins as a potential source of IL-22 in adults with AD, which is relevant for the maintenance of immunological imbalance. (AU) | |
| Processo FAPESP: | 14/25645-7 - Avaliação fenotípica e funcional de células dendríticas inflamatórias e de células T na dermatite atópica do adulto |
| Beneficiário: | Valeria Aoki |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 16/24161-1 - Caracterização proteômica de exossomas do plasma e de fibroblastos dérmicos na dermatite atópica do adulto |
| Beneficiário: | Raquel Leão Orfali |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |