Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia

Autor(es)

Fachim, Helene A. ^[1] ; Srisawat, Umarat ^[1] ; Dalton, Caroline F. ^[1] ; Reynolds, Gavin P. ^[1]

Afiliação do(s) autor(es)

^[1] Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire - England

• Tipo de documento: Artigo Científico
• Fonte: Epigenomics; v. 10, n. 5, p. 519-524, MAY 2018.
• Citações Web of Science: 5

Resumo

Deficits of brain parvalbumin (PV) are a consistent finding in schizophrenia and models of psychosis. We investigated whether this is associated with abnormal PV gene (PVALB) methylation in the brain in schizophrenia. Bisulfite pyrosequencing was used to determine cytosine (CpG) methylation in a PVALB promoter sequence. Greater PVALB methylation was found in schizophrenia hippocampus, while no differences were observed in prefrontal cortex. LINE-1 methylation, a measure of global methylation, was also elevated in both regions in schizophrenia, although the PVALB change was independent of this effect. These results provide the first evidence that PVALB promoter methylation is abnormal in schizophrenia and suggest that this epigenetic finding may relate to the reduction of PV expression seen in the disease. (AU)

• Processo FAPESP: 17/00624-5 - Investigação na metilação do DNA em pacientes em primeiro episódio psicótico e em animais submetidos ao isolamento social a partir do desmame nos dois principais sistemas excitatório e inibitório
• Beneficiário: Helene Aparecida Fachim
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado