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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Parvalbumin promoter hypermethylation in postmortem brain in schizophrenia

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Author(s):
Fachim, Helene A. [1] ; Srisawat, Umarat [1] ; Dalton, Caroline F. [1] ; Reynolds, Gavin P. [1]
Total Authors: 4
Affiliation:
[1] Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire - England
Total Affiliations: 1
Document type: Journal article
Source: Epigenomics; v. 10, n. 5, p. 519-524, MAY 2018.
Web of Science Citations: 5
Abstract

Deficits of brain parvalbumin (PV) are a consistent finding in schizophrenia and models of psychosis. We investigated whether this is associated with abnormal PV gene (PVALB) methylation in the brain in schizophrenia. Bisulfite pyrosequencing was used to determine cytosine (CpG) methylation in a PVALB promoter sequence. Greater PVALB methylation was found in schizophrenia hippocampus, while no differences were observed in prefrontal cortex. LINE-1 methylation, a measure of global methylation, was also elevated in both regions in schizophrenia, although the PVALB change was independent of this effect. These results provide the first evidence that PVALB promoter methylation is abnormal in schizophrenia and suggest that this epigenetic finding may relate to the reduction of PV expression seen in the disease. (AU)

FAPESP's process: 17/00624-5 - DNA methylation investigation in first episode of psychosis and in rats undergoing isolation rearing from weaning in the two major excitatory and inhibitory systems
Grantee:Helene Aparecida Fachim
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor