Action and function of Faecalibacterium prausnitzii in health and disease

Autor(es)

Ferreira-Halder, Carmen Verissima ^[1] ; de Sousa Faria, Alessandra Valeria ^[1] ; Andrade, Sheila Siqueira ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Sao Paulo - Brazil

^[2] Plateinnove Biotechnol, 1131 Limeira Ave, RM 10, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY; v. 31, n. 6, p. 643-648, DEC 2017.
• Citações Web of Science: 21

Resumo

Faecalibacterium prausnitzii, anaerobic bacteria, is one of the main components of gut microbiota and the most important butyrate-producing bacteria in the human colon. So far, this commensal bacterium has been considered as a bioindicator of human health, once when its population is altered (decreased), inflammatory processes are favored. Several reports in the literature highlighted that the amount of Faecalibacterium prausnitzii negatively correlates to the activity of inflammatory bowel disease and colorectal cancer. Therefore, counterbalancing dysbiosis using Faecalibacterium prausnitzii as a potential active component of probiotic formulations appears to be a promising therapeutic strategy for inflammatory bowel diseases and colorectal cancer. However, once this microbial is very sensitive to oxygen, the formulation development is a great challenge. In this review, we will focus our attention on Faecalibacterium prausnitzii biology, anti-inflammatory metabolites, modulators of this bacterium population and its impact on human health. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 15/20412-7 - Proteína tirosina fosfatase de baixo peso molecular em câncer de cólon retal: da bancada à geração de produto
• Beneficiário: Carmen Veríssima Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/14459-3 - Lisado plaquetário humano: do descarte a produtos de alto valor agregado direcionados à terapia celular e à medicina moderna
• Beneficiário: Sheila Siqueira Andrade
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE