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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Action and function of Faecalibacterium prausnitzii in health and disease

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Author(s):
Ferreira-Halder, Carmen Verissima [1] ; de Sousa Faria, Alessandra Valeria [1] ; Andrade, Sheila Siqueira [2]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Sao Paulo - Brazil
[2] Plateinnove Biotechnol, 1131 Limeira Ave, RM 10, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY; v. 31, n. 6, p. 643-648, DEC 2017.
Web of Science Citations: 21
Abstract

Faecalibacterium prausnitzii, anaerobic bacteria, is one of the main components of gut microbiota and the most important butyrate-producing bacteria in the human colon. So far, this commensal bacterium has been considered as a bioindicator of human health, once when its population is altered (decreased), inflammatory processes are favored. Several reports in the literature highlighted that the amount of Faecalibacterium prausnitzii negatively correlates to the activity of inflammatory bowel disease and colorectal cancer. Therefore, counterbalancing dysbiosis using Faecalibacterium prausnitzii as a potential active component of probiotic formulations appears to be a promising therapeutic strategy for inflammatory bowel diseases and colorectal cancer. However, once this microbial is very sensitive to oxygen, the formulation development is a great challenge. In this review, we will focus our attention on Faecalibacterium prausnitzii biology, anti-inflammatory metabolites, modulators of this bacterium population and its impact on human health. (C) 2017 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/20412-7 - Low molecular weight protein tyrosine phosphatase in colorectal cancer: from the bench to product generation
Grantee:Carmen Veríssima Ferreira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/14459-3 - Human platelet lysate: from discard to value products in cell therapy and advanced cell-based medicine
Grantee:Sheila Siqueira Andrade
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE