Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies

Autor(es)

Mueller-Coan, Barbara Grasiele ^{[1, 2]} ; Ramos Caetano, Brunno Felipe ^{[1, 2]} ; Pagano, Joseph Stephen ^[3] ; de Oliveira, Deilson Elgui ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Med Sch Botucatu, Av Prof Mario Rubens Guimaraes Montenegro S-N, BR-18618687 Botucatu, SP - Brazil

^[2] UNESP, Inst Biotechnol IBTEC, AlamedadasTecomarias S-N, BR-18607440 Botucatu, SP - Brazil

^[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: TRENDS IN CANCER; v. 4, n. 7, p. 485-498, JUL 2018.
• Citações Web of Science: 3

Resumo

Cancer progression is the most relevant phase of carcinogenesis due to the development of malignant tumors in the host. Some viruses participate in malignant cell transformation, with recent compelling evidence suggesting that oncoviruses also have a role in cancer progression. The human hepatitis B (HBV) and C (HCV) viruses, human papillomaviruses (HPV), Epstein Barr virus (EBV), and Kaposi sarcoma herpesvirus (KSHV) are the most important human oncoviruses currently known. Here, we discuss how oncoviruses can modulate cancer progression, such as tumor growth, invasion, and cancer metastasis. (AU)

• Processo FAPESP: 14/17326-9 - Efeitos da proteína LMP1 dos isolados B95-8 e M81 do vírus de Epstein-Barr no potencial de invasão de células de carcinoma humano e na regulação de microRNAs endógenos e proteínas implicados na progressão de cânceres
• Beneficiário: Deilson Elgui de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular