The role of tannins as antiulcer agents: a fluorescence-imaging based study

Autor(es)

Demarque, Daniel P. ^[1] ; Callejon, Daniel R. ^[1] ; de Oliveira, Gibson G. ^{[1, 2]} ; Silva, Denise B. ^[3] ; Carollo, Carlos A. ^[3] ; Lopes, Norberto P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Nucleo Pesquisa Prod Nat & Sintet, Ribeirao Preto, SP - Brazil

^[2] Fac Escritor Osman da Costa Lins, Vitoria De Santo Antao, PE - Brazil

^[3] Univ Fed Mato Grosso do Sul, Ctr Ciencias Biol & Saude, Lab Prod Nat & Espectrometria Massas, Grande, MS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 28, n. 4, p. 425-432, JUL-AUG 2018.
• Citações Web of Science: 2

Resumo

Condensed tannins have been used for many years in folk medicine to treat gastric problems. The mechanism of action that explains why tannins improve gastritis symptoms is based on their ability to chelate metals, antioxidant activity, and their complexation power with other molecules. Even though these uses are well-known, the requirements to become an herbal medicine are much more complex. Herein, we analyzed Stryphnodendron rotundifolium Mart., Fabaceae, extract using MALDI for tannin characterization and carried out a fluorescence-imaging study to prove the gastroprotective effects of tannins as coating agents. Through these methods we show that condensed tannins form a gastroprotective layer. Moreover, we revise and discuss other possible mechanisms of action for phenolic-rich plant extracts and their potential in the development of herbal medicines to treat ulcers and gastritis. (C) 2018 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. (AU)

• Processo FAPESP: 14/50265-3 - Metabolismo e distribuição de xenobióticos naturais e sintéticos: da compreensão dos processos reacionais à geração de imagens teciduais
• Beneficiário: Norberto Peporine Lopes
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático
• Processo FAPESP: 14/18052-0 - Histolocalização de taninos e antraquinonas com atuação no sistema gastrointestinal
• Beneficiário: Daniel Pecoraro Demarque
• Linha de fomento: Bolsas no Brasil - Doutorado