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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of tannins as antiulcer agents: a fluorescence-imaging based study

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Author(s):
Demarque, Daniel P. [1] ; Callejon, Daniel R. [1] ; de Oliveira, Gibson G. [1, 2] ; Silva, Denise B. [3] ; Carollo, Carlos A. [3] ; Lopes, Norberto P. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Nucleo Pesquisa Prod Nat & Sintet, Ribeirao Preto, SP - Brazil
[2] Fac Escritor Osman da Costa Lins, Vitoria De Santo Antao, PE - Brazil
[3] Univ Fed Mato Grosso do Sul, Ctr Ciencias Biol & Saude, Lab Prod Nat & Espectrometria Massas, Grande, MS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 28, n. 4, p. 425-432, JUL-AUG 2018.
Web of Science Citations: 3
Abstract

Abstract Condensed tannins have been used for many years in folk medicine to treat gastric problems. The mechanism of action that explains why tannins improve gastritis symptoms is based on their ability to chelate metals, antioxidant activity, and their complexation power with other molecules. Even though these uses are well-known, the requirements to become an herbal medicine are much more complex. Herein, we analyzed Stryphnodendron rotundifolium Mart., Fabaceae, extract using MALDI for tannin characterization and carried out a fluorescence-imaging study to prove the gastroprotective effects of tannins as coating agents. Through these methods we show that condensed tannins form a gastroprotective layer. Moreover, we revise and discuss other possible mechanisms of action for phenolic-rich plant extracts and their potential in the development of herbal medicines to treat ulcers and gastritis. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 14/18052-0 - Tissue localization of tannins and Anthraquinones acting on gastrointestinal system
Grantee:Daniel Pecoraro Demarque
Support Opportunities: Scholarships in Brazil - Doctorate