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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Low Rates of Poliovirus Antibodies in Primary Immunodeficiency Patients on Regular Intravenous Immunoglobulin Treatment

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Autor(es):
Costa-Carvalho, Beatriz T. [1] ; Sullivan, Kathleen E. [2] ; Fontes, Patricia M. [3, 1] ; Aime-Nobre, Fernanda [1] ; Gonzales, Isabela G. S. [1] ; Lima, Elaine S. [4] ; Granato, Celso [4] ; de Moraes-Pinto, Maria Isabel [3, 5]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, Sao Paulo - Brazil
[2] Univ Penn, Div Allergy Immunol, Childrens Hosp Philadelphia, Perelman Sch Med, Philadelphia, PA 19104 - USA
[3] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Med, Div Infect Dis, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Div Pediat Infect Dis, Res Lab, Rua Pedro Toledo, 781-9 Andar, BR-04039032 Sao Paulo, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL IMMUNOLOGY; v. 38, n. 5, p. 628-634, JUL 2018.
Citações Web of Science: 0
Resumo

Poliovirus has been nearly eliminated as part of a world-wide effort to immunize and contain circulating wild-type polio. Nevertheless, poliovirus has been detected in water supplies and represents a threat to patients with humoral immunodeficiencies where infection can be fatal. To define the risk, we analyzed antibodies to poliovirus 1, 2, and 3 in serum samples collected over a year from patients with primary immunodeficiency diseases (PID) on regular intravenous immunoglobulin (IVIG) replacement. Twenty-one patients on regular IVIG replacement therapy were evaluated: Twelve patients with common variable immune deficiency (CVID), six with X-linked agammaglobulinemia (XLA), and three with hyper IgM syndrome (HIGM). Over 1 year, four blood samples were collected from each of these patients immediately before immunoglobulin infusion. One sample of IVIG administered to each patient in the month before blood collection was also evaluated. Poliovirus antibodies were quantified by seroneutralization assay. All IVIG samples had detectable antibodies to the three poliovirus serotypes. Despite that, only 52.4, 61.9, and 19.0% of patients showed protective antibody titers for poliovirus 1, 2, and 3, respectively. Only two patients (9.5%) had protective antibodies for the three poliovirus serotypes on all samples. Most patients were therefore susceptible to all three poliovirus serotypes. This study demonstrates the need for ongoing vigilance regarding exposure of patients with PID to poliovirus in the community. (AU)

Processo FAPESP: 11/06136-6 - Anticorpos séricos contra o vírus da poliomielite em pacientes com imunodeficiência primária em uso de imunoglobulina humana intravenosa
Beneficiário:Beatriz Tavares Costa Carvalho
Linha de fomento: Auxílio à Pesquisa - Regular