Vitamin D treatment abrogates the inflammatory response in paraquat-induced lung fibrosis

Autor(es)

Schapochnik, Adriana ^[1] ; da Silva, Marcia Rodrigues ^[1] ; Leal, Mayara Peres ^[1] ; Esteves, Janete ^[1] ; Hebeda, Cristina Bichels ^[2] ; Sandri, Silvana ^[2] ; Teixeira da Silva, Daniela de Fatima ^[1] ; Poliseli Farsky, Sandra Helena ^[2] ; Marcos, Rodrigo Labat ^[1] ; Lino-dos-Santos-Franco, Adriana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Nove de Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Brazil Rua Vergueiro 239-245, BR-01504000 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Toxicology and Applied Pharmacology; v. 355, p. 60-67, SEP 15 2018.
• Citações Web of Science: 5

Resumo

A high incidence of intentional or accidental paraquat (PQ) ingestion is related to irreversible lung fibrosis and no effective therapy is currently available. Vitamin D has emerged with promising results as an immunomodulatory molecule when abrogating the inflammatory responses of lung diseases. Therefore, we have investigated the role of vitamin D treatments on PQ-induced lung fibrosis in male C57/BL6 mice. Lung fibrosis was induced by a single injection of PQ (10 mg/kg; i.p.). The control group received PQ vehicle. Seven days later, after the PQ injection or the vehicle injection, the mice received vitamin D (5 mu g/kg, i.p., once a day) or vehicle, for a further 7 days. Twenty-four hours after the last dose of vitamin D or the vehicle, the analysis were performed. The vitamin D treatments reduced the number of leukocytes in their BALF and they decreased the IL-6, IL-17, TGF-beta and MMP-9 levels and the abrogated collagenase deposits in their lung tissues. Conversely, the vitamin D treatments increased the resolvin D levels in their BALF. Moreover, their tracheal contractility was also significantly reduced by the vitamin D treatments. Altogether, the data that was obtained showed a promising use of vitamin D, in treating the lung fibrosis that had been induced by the PQ intoxications. This may improve its prognostic use for a non-invasive and low cost therapy. (AU)

• Processo FAPESP: 17/06444-9 - Avaliação do tratamento com LED na resolução da lesão pulmonar aguda induzida por sepse
• Beneficiário: Adriana Lino dos Santos Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular