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Relationship of runs of homozygosity with adaptive and production traits in a paternal broiler line

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Autor(es):
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Marchesi, J. A. P. [1, 2] ; Buzanskas, M. E. [3] ; Cantao, M. E. [4] ; Ibelli, A. M. G. [4] ; Peixoto, J. O. [4] ; Joaquim, L. B. [2] ; Moreira, G. C. M. [5] ; Godoy, T. F. [5] ; Sbardella, A. P. [2] ; Figueiredo, E. A. P. [4] ; Coutinho, L. L. [5] ; Munari, D. P. [2] ; Ledur, M. C. [4]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Estadual Paulista Unesp, Fac Ciencias Agr & Vet, Dept Ciencias Exatas, Via Acesso Prof Paulo Donato Castelane S-N, BR-14884900 Jaboticabal, SP - Brazil
[3] Univ Fed Paraiba UFPB, Ctr Ciencias Agr, Dept Zootecnia, Campus 2, Rodovia BR 079, Km 12, BR-58397000 Areia, Paraiba - Brazil
[4] Embrapa Suinos & Aves, Rodovia BR 153, Km 110, Caixa Postal 321, BR-89715899 Concordia, SC - Brazil
[5] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Zootecnia, Av Padua Dias 11, BR-13419900 Piracicaba, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: ANIMAL; v. 12, n. 6, p. 1126-1134, JUN 2018.
Citações Web of Science: 1
Resumo

Genomic regions under high selective pressure present specific runs of homozygosity (ROH), which provide valuable information on the genetic mechanisms underlying the adaptation to environment imposed challenges. In broiler chickens, the adaptation to conventional production systems in tropical environments lead the animals with favorable genotypes to be naturally selected, increasing the frequency of these alleles in the next generations. In this study, similar to 1400 chickens from a paternal broiler line were genotyped with the 600 K Affymetrix (R) Axiom (R) high-density (HD) genotyping array for estimation of linkage disequilibrium (LD), effective population size (N-e), inbreeding and ROH. The average LD between adjacent single nucleotide polymorphisms (SNPs) in all autosomes was 0.37, and the LD decay was higher in microchromosomes followed by intermediate and macrochromosomes. The N-e of the ancestral population was high and declined over time maintaining a sufficient number of animals to keep the inbreeding coefficient of this population at low levels. The ROH analysis revealed genomic regions that harbor genes associated with homeostasis maintenance and immune system mechanisms, which may have been selected in response to heat stress. Our results give a comprehensive insight into the relationship between shared ROH regions and putative regions related to survival and production traits in a paternal broiler line selected for over 20 years. These findings contribute to the understanding of the effects of environmental and artificial selection in shaping the distribution of functional variants in the chicken genome. (AU)

Processo FAPESP: 14/08704-0 - Identificação de locos de interesse zootécnico na galinha doméstica
Beneficiário:Luiz Lehmann Coutinho
Linha de fomento: Auxílio à Pesquisa - Temático