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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy

Texto completo
Autor(es):
Seno, Midia D. J. [1] ; Assis, Danielle V. [1] ; Gouveia, Flavia [1] ; Antunes, Geiza F. [1] ; Kuroki, Mayra [1] ; Oliveira, Caroline C. [1] ; Santos, Lennon C. T. [1] ; Pagano, Rosana L. [1] ; Martinez, Raquel C. R. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Hosp Sirio Libanes, Lab Neurosci, Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 8, SEP 11 2018.
Citações Web of Science: 6
Resumo

The amygdala is an important component of the limbic system that participates in the control of the pain response and modulates the affective-motivational aspect of pain. Neuropathic pain is a serious public health problem and has a strong affective-motivational component that makes it difficult to treat. The central (CeA), basolateral (BLA) and lateral (LA) nuclei of the amygdala are involved in the processing and regulation of chronic pain. However, the roles of these nuclei in the maintenance of neuropathic pain, anxiety and depression remain unclear. Thus, the main objective of this study was to investigate the role of amygdala subnuclei in the modulation of neuropathic pain, including the affective-motivational axis, in an experimental model of peripheral neuropathy. The specific goals were as follows: (1) To evaluate the nociceptive responses and the patterns of activation of the CeA, BLA and LA in neuropathic rats; and (2) To evaluate the effect of inactivating the amygdala nuclei on the nociceptive response, anxiety and depressive behaviors, motor activity, and plasma stress hormones in animals with neuropathic pain. Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naive rats. Once the amygdala subnuclei involved in neuropathic pain response were defined, those subnuclei were pharmacological inactivated. The effect of muscimol inactivation on the nociceptive response (hyperalgesia and allodynia), anxiety (elevated plus-maze), depressive-like behavior (forced swim test), motor activity (open field), and plasma stress hormone levels (corticosterone and adrenocorticotropic hormone) were evaluated in sham-operated and neuropathic animals. The results showed that the anterior and posterior portions of the BLA and the central portion of the CeA are involved in controlling neuropathic pain. The inactivation of these nuclei reversed hyperalgesia, allodynia and depressive-like behavior in animals with peripheral neuropathy. Taken together, our findings improve our understanding of the neurocircuitry involved in persistent pain and the roles of specific amygdala subnuclei in the modulation of neuropathic pain, including the neurocircuitry that processes the affective-motivational component of pain. (AU)

Processo FAPESP: 15/26079-8 - Participação da via de analgesia serotoninérgica descendente e alteração da resposta inflamatória e neurodegenerativa no tratamento da dor neuropática pela estimulação transcraniana por corrente contínua
Beneficiário:Rosana de Lima Pagano
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/03039-5 - Papel dos níveis plasmáticos de corticosterona em animais com desempenho bom e ruim no teste da aprendizagem aversiva
Beneficiário:Caroline Cruz de Oliveira
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 11/08575-7 - Papel da modulação dopaminérgica no núcleo lateral da amígdala sobre a resposta condicionada de esquiva
Beneficiário:Raquel Chacon Ruiz Martinez
Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
Processo FAPESP: 14/12999-5 - Avaliação do fator linhagem nos níveis de ansiedade em animais com desempenho bom e ruim no teste da aprendizagem aversiva: Wistar versus Sprague Dawley
Beneficiário:Lennon Tosati Cardoso Dos Santos
Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/20602-5 - Análise prospectiva dos resultados funcionais da amigdalotomia bilateral assistencial em pacientes com agressividade refratária
Beneficiário:Flavia Venetucci Gouveia
Modalidade de apoio: Bolsas no Brasil - Doutorado