| Texto completo | |
| Autor(es): |
Neves, Lia M. G.
[1]
;
Parizotto, Nivaldo A.
[2, 3, 4]
;
Cominetti, Marcia R.
[1]
;
Bayat, Ardeshir
[5]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Carlos, Dept Gerontol, Lab Biol Aging LABEN, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Phys Therapy Dept, Sao Carlos, SP - Brazil
[3] Univ Araraquara, Biotechnol Postgrad Program, Araraquara - Brazil
[4] Univ Brazil, Postgrad Biomed Engn, Sao Paulo, SP - Brazil
[5] Univ Manchester, Div Musculoskeletal & Dermatol Sci, Sch Biol Sci & Hlth, Manchester, Lancs - England
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Biophotonics; v. 11, n. 9 SEP 2018. |
| Citações Web of Science: | 0 |
| Resumo | |
The use of dermal substitutes to treat skin defects such as ulcers has shown promising results, suggesting a potential role for skin substitutes for treating acute and chronic wounds. One of the main drawbacks with the use of dermal substitutes is the length of time from engraftment to graft take, plus the risk of contamination and failure due to this prolonged integration. Therefore, the use of adjuvant energy-based therapeutic modalities to augment and accelerate the rate of biointegration by dermal substitute engraftments is a desirable outcome. The photobiomodulation (PBM) therapy modulates the repair process, by stimulating cellular proliferation and angiogenesis. Here, we evaluated the effect of PBM on a collagen-glycosaminoglycan flowable wound matrix (FWM) in an ex vivo human skin wound model. PBM resulted in accelerated rate of re-epithelialization and organization of matrix as seen by structural arrangement of collagen fibers, and a subsequent increased expression of alpha-smooth muscle actin (alpha-SMA) and vascular endothelial growth factor A (VEGF-A) leading to an overall improved healing process. The use of PBM promoted a beneficial effect on the rate of integration and healing of FWM. We therefore propose that the adjuvant use of PBM may have utility in enhancing engraftment and tissue repair and be of value in clinical practice. (AU) | |
| Processo FAPESP: | 16/24907-3 - Efeitos da fotobiomodulação e do modelo dermal Integra® suplementado com fração de polissacarídeos de Lycium barbarum em um modelo de cicatrização de ferida ex vivo |
| Beneficiário: | Lia Mara Grosso Neves |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |