Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension

Autor(es)

Duchatsch, Francine ^{[1, 2]} ; Constantino, Paula B. ^{[1, 2]} ; Herrera, Naiara A. ^{[1, 2]} ; Fabricio, Mayara F. ^{[1, 2]} ; Tardelli, Lidieli P. ^{[1, 2]} ; Martuscelli, Aline M. ^[2] ; Dionisio, Thiago J. ^[3] ; Santos, Carlos F. ^[3] ; Amaral, Sandra L. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] UNESP, Joint Grad Program Physiol Sci, PIPGCF UFSCar, Sao Carlos, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Sci Fac, Dept Phys Educ, Bauru, SP - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION; v. 12, n. 8, p. 605-613, AUG 2018.
• Citações Web of Science: 0

Resumo

Hypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P <.05) and a significant reduction of parasympathetic component (-18.02%, P <.05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system. (C) 2018 American Heart Association. All rights reserved. (AU)

• Processo FAPESP: 14/23050-6 - Efeitos do tratamento agudo e de curta duração com dexametasona: papel do sistema renina angiotensina e do sistema nervoso autônomo
• Beneficiário: Francine Duchatsch Ribeiro de Souza
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 15/03965-2 - Papel do sistema renina-angiotensina em diferentes modelos inflamatórios orais: uma abordagem interdisciplinar experimental e clínica
• Beneficiário: Carlos Ferreira dos Santos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/19722-3 - Efeitos do pré-condicionamento físico na hipertensão induzida pela dexametasona: papel do sistema renina angiotensina
• Beneficiário: Paula Bessi Constantino Prazeres
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/23229-6 - Efeitos do treinamento físico na hipertensão, enrijecimento arterial e atrofia muscular induzidos por dexametasona: papel do estresse oxidativo
• Beneficiário: Sandra Lia do Amaral Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular