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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory

Texto completo
Autor(es):
Balthazar, Janaina [1] ; Schowe, Natalia Mendes [1] ; Cipolli, Gabriela Cabett [2] ; Buck, Hudson Sousa [3] ; Viel, Tania Araujo [2, 1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil
[3] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Fac Ciencias Med, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN AGING NEUROSCIENCE; v. 10, SEP 26 2018.
Citações Web of Science: 1
Resumo

Alzheimer's disease (AD) is associated with a progressive dementia, and there is good evidence that it is more pronounced in individuals that have fewer stimuli during their lives. Environmental stimulation promotes morphological and functional changes in the brain, leading to amplification of cognitive functions, and has been described in humans and animals. In this study, we evaluated the effects of enriched environment (EE) stimulation on spatial memory and senile plaque formation in transgenic mice PDGFB-APPSwInd (TG) that overexpress the human amyloid precursor protein, normally resulting in an increased density of senile plaques. We compared this group of EE stimulated transgenic mice (TG-EE) with an EE stimulated control group of age-matched C57Bl/6 wild type animals (WT-EE). Both groups were exposed to EE stimulation between the ages of 8 and 12 months. As controls of the experiment, there were a group of TG mice not exposed to EE (TG-Ctrl) and a group of WT mice not exposed to EE (WT-Ctrl). The TG-EE group presented improved spatial memory when compared to the TG-Ctrl animals. In addition, the TG-EE group showed a 69.2% reduction in the total density of senile plaques in the hippocampus when compared to the TG-Ctrl group. In this group, the concentration of senile plaques was greater in the dorsal part of the hippocampus, which is linked to spatial localization, and the reduction of this density after the submission to EE was as high as 85.1%. EE stimulation had no effect on the density of amyloid-beta (A beta) oligomers. However, amyloid scavenger receptor class B member 1 (SR-B1) density was significantly decreased in the TG-Ctrl mice, but not in the TG-EE mice, suggesting that cognitive stimulation had an effect on the formation of a cognitive reserve that could prevent the accumulation of senile plaques. It is suggested that the stimulation of old mice by EE for 4 months led to the formation of brain resilience that protected the brain from the deposition of senile plaques, one of the hallmarks of AD, leading to improvement in spatial memory. (AU)

Processo FAPESP: 13/19999-8 - Estudo das alterações moleculares colinérgicas que ocorrem após a aplicação de estratégias não-farmacológicas para melhora da memória
Beneficiário:Natália Mendes Schowe
Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
Processo FAPESP: 16/07115-6 - Estudo translacional de estratégias e biomarcadores para a promoção da longevidade saudável
Beneficiário:Tânia Araújo Viel
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/06935-1 - Avaliação de alterações em placas senis e marcadores colinérgicos no cérebro de camundongos submetidos a um modelo de neurodegeneração, após treino de atenção
Beneficiário:Gabriela Cabett Cipolli
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/13656-1 - Estudo do possível papel neuroprotetor do receptor B2 para bradicinina na Doença de Alzheimer
Beneficiário:Hudson de Sousa Buck
Linha de fomento: Auxílio à Pesquisa - Regular