Enriched Environment Significantly Reduced Senile Plaques in a Transgenic Mice Model of Alzheimer's Disease, Improving Memory

Autor(es)

Balthazar, Janaina ^[1] ; Schowe, Natalia Mendes ^[1] ; Cipolli, Gabriela Cabett ^[2] ; Buck, Hudson Sousa ^[3] ; Viel, Tania Araujo ^{[2, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

^[3] Santa Casa Sao Paulo Sch Med Sci, Dept Physiol Sci, Fac Ciencias Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN AGING NEUROSCIENCE; v. 10, SEP 26 2018.
• Citações Web of Science: 1

Resumo

Alzheimer's disease (AD) is associated with a progressive dementia, and there is good evidence that it is more pronounced in individuals that have fewer stimuli during their lives. Environmental stimulation promotes morphological and functional changes in the brain, leading to amplification of cognitive functions, and has been described in humans and animals. In this study, we evaluated the effects of enriched environment (EE) stimulation on spatial memory and senile plaque formation in transgenic mice PDGFB-APPSwInd (TG) that overexpress the human amyloid precursor protein, normally resulting in an increased density of senile plaques. We compared this group of EE stimulated transgenic mice (TG-EE) with an EE stimulated control group of age-matched C57Bl/6 wild type animals (WT-EE). Both groups were exposed to EE stimulation between the ages of 8 and 12 months. As controls of the experiment, there were a group of TG mice not exposed to EE (TG-Ctrl) and a group of WT mice not exposed to EE (WT-Ctrl). The TG-EE group presented improved spatial memory when compared to the TG-Ctrl animals. In addition, the TG-EE group showed a 69.2% reduction in the total density of senile plaques in the hippocampus when compared to the TG-Ctrl group. In this group, the concentration of senile plaques was greater in the dorsal part of the hippocampus, which is linked to spatial localization, and the reduction of this density after the submission to EE was as high as 85.1%. EE stimulation had no effect on the density of amyloid-beta (A beta) oligomers. However, amyloid scavenger receptor class B member 1 (SR-B1) density was significantly decreased in the TG-Ctrl mice, but not in the TG-EE mice, suggesting that cognitive stimulation had an effect on the formation of a cognitive reserve that could prevent the accumulation of senile plaques. It is suggested that the stimulation of old mice by EE for 4 months led to the formation of brain resilience that protected the brain from the deposition of senile plaques, one of the hallmarks of AD, leading to improvement in spatial memory. (AU)

• Processo FAPESP: 13/19999-8 - Estudo das alterações moleculares colinérgicas que ocorrem após a aplicação de estratégias não-farmacológicas para melhora da memória
• Beneficiário: Natália Mendes Schowe
• Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
• Processo FAPESP: 16/07115-6 - Estudo translacional de estratégias e biomarcadores para a promoção da longevidade saudável
• Beneficiário: Tânia Araújo Viel
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/06935-1 - Avaliação de alterações em placas senis e marcadores colinérgicos no cérebro de camundongos submetidos a um modelo de neurodegeneração, após treino de atenção
• Beneficiário: Gabriela Cabett Cipolli
• Linha de fomento: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 13/13656-1 - Estudo do possível papel neuroprotetor do receptor B2 para bradicinina na Doença de Alzheimer
• Beneficiário: Hudson de Sousa Buck
• Linha de fomento: Auxílio à Pesquisa - Regular