Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds

Autor(es)

Dametto, Alessandra C. ^{[1, 2]} ; Boralle, Nivaldo ^[1] ; Zhang, Chuan-Rui ^{[2, 3]} ; Silva, Dulce H. S. ^[1] ; Nair, Muraleedharan G. ^[2]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, NuBBE Nucleus Bioassays Biosynth & Ecophysiol Nat, Inst Chem, Dept Organ Chem, BR-14800060 Araraquara, SP - Brazil

^[2] Michigan State Univ, Dept Hort, Bioact Nat Prod & Phytoceut Lab, E Lansing, MI 48824 - USA

^[3] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331 - Peoples R China

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT COMMUNICATIONS; v. 13, n. 8, p. 977-980, AUG 2018.
• Citações Web of Science: 1

Resumo

Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8'R-7,8,7',8'-tetrahydro-8,8'-dimethyl-3,3'-dimethoxy-4,4'-dihydr oxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 04/07932-7 - Busca de compostos naturais antitumorais, antioxidantes, antiinflamatórios, antidiabéticos, inibidores de acetilcolinesterase e mieloperoxidase no Cerrado e na Mata Atlântica
• Beneficiário: Dulce Helena Siqueira Silva
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático