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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds

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Author(s):
Dametto, Alessandra C. [1, 2] ; Boralle, Nivaldo [1] ; Zhang, Chuan-Rui [2, 3] ; Silva, Dulce H. S. [1] ; Nair, Muraleedharan G. [2]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, NuBBE Nucleus Bioassays Biosynth & Ecophysiol Nat, Inst Chem, Dept Organ Chem, BR-14800060 Araraquara, SP - Brazil
[2] Michigan State Univ, Dept Hort, Bioact Nat Prod & Phytoceut Lab, E Lansing, MI 48824 - USA
[3] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331 - Peoples R China
Total Affiliations: 3
Document type: Journal article
Source: NATURAL PRODUCT COMMUNICATIONS; v. 13, n. 8, p. 977-980, AUG 2018.
Web of Science Citations: 1
Abstract

Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8'R-7,8,7',8'-tetrahydro-8,8'-dimethyl-3,3'-dimethoxy-4,4'-dihydr oxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL. (AU)

FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 04/07932-7 - Search for potential antitumoral, antioxidant, antiinflammatory, antidiabetic, acetylcholinesterase and mieloperoxidase inhibitory natural compounds from Cerrado and Atlantic Forest
Grantee:Dulce Helena Siqueira Silva
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants