Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties

Autor(es)

Sartim, Marco Aurelio ^[1] ; Menaldo, Danilo Luccas ^[1] ; Sampaio, Suely Vilela ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 24, DEC 17 2018.
• Citações Web of Science: 1

Resumo

Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, opening novel perspectives and applications as a therapeutic approach. Although this toxin acts on a wide variety of biological events, the modulation of immune responses is considered as one of its most relevant behaviors. Therefore, the present review describes the scientific investigations on the capacity of Crotoxin to modulate anti-inflammatory and immunosuppressive responses, and its application as a medicinal immunopharmacological approach. In addition, this review will also discuss its mechanisms, involving cellular and molecular pathways, capable of improving pathological alterations related to immune-associated disorders. (AU)

• Processo FAPESP: 15/06290-6 - Avaliação do potencial anti-inflamatório da crotoxina, uma fosfolipase A2 isolada da peçonha de Crotalus durissus terrificus, em modelo de coagulação intravascular disseminada induzida por endotoxemia
• Beneficiário: Marco Aurélio Sartim
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/23236-4 - Toxinas animais nativas e recombinantes: análise funcional, estrutural e molecular
• Beneficiário: Suely Vilela
• Modalidade de apoio: Auxílio à Pesquisa - Temático