Gene expression profiling of triple-negative breast tumors with different expression of secreted protein acidic and cysteine rich (SPARC)

Autor(es)

de Alcantara Filho, Paulo R. ^{[1, 2, 3]} ; Mangone, Flavia R. ^[2] ; Pavanelli, Ana C. ^[2] ; de Bessa Garcia, Simone A. ^{[1, 2]} ; Nonogaki, Suely ^[4] ; de Toledo Osorio, Cynthia A. B. ^[4] ; de Andrade, Victor P. ^[4] ; Nagai, Maria A. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept Radiol & Oncol, Discipline Oncol, BR-01246903 Sao Paulo - Brazil

^[2] Canc Inst State Sao Paulo ICESP, Ctr Translat Res Oncol, Lab Mol Genet, BR-01246000 Sao Paulo - Brazil

^[3] AC Camargo Canc Ctr, Dept Breast Surg, BR-01509020 Sao Paulo - Brazil

^[4] AC Camargo Canc Ctr, Dept Pathol, BR-01509020 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BREAST CANCER MANAGEMENT; v. 7, n. 2 MAY 2018.
• Citações Web of Science: 0

Resumo

Aim: To determine the expression signature of triple-negative breast cancer (TNBC) with differences of secreted protein acidic and rich in cysteine expression and clinical behavior. Patients, materials \& methods: cDNA microarray analysis was performed to determine the expression profiling of TNBC, characterized regarding secreted protein acidic and rich in cysteine expression status. Immunohistochemistry analysis on tissue microarrays containing an independent cohort of TNBC was performed for validation. Results: Negative staining of SOHLH2 and positive staining of DNAJC12 and LIM1 was correlated with a poor outcome of the patients. Conclusion: Our findings provide new information on transcriptome changes associated with the clinical behavior of TNBC that may serve as a potential tool for the identification and characterization of new candidate biomarkers. (AU)

• Processo FAPESP: 13/07035-4 - Avaliação do papel funcional da expressão intra- e extracelular de PAR-4 (prostate apoptosis response-4) na tumorigênese da mama: implicações na quimiosensibilidade e potencial antitumoral
• Beneficiário: Maria Aparecida Nagai
• Modalidade de apoio: Auxílio à Pesquisa - Regular