Sjogren's syndrome and systemic lupus erythematosus: links and risks

Autor(es)

Pasoto, Sandra Gofinet ^{[1, 2]} ; de Oliveira Martins, Victor Adriano ^[1] ; Bonfa, Eloisa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Rheumatol Div, Hosp Clin, Ave Dr Arnaldo, 455, 3 Andar, Sala 3190, BR-01246903 Sao Paulo, SP - Brazil

^[2] Univ Paulo HCFMUSP, Fac Med, Lab Div, Hosp Clin, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS; v. 11, p. 33-45, 2019.
• Citações Web of Science: 4

Resumo

Systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS) may coexist, and they are chronic complex disorders, with an autoimmune background, multifactorial etiology, multiple circulating autoantibodies, and variable prognosis. The prominent feature of SS is the impairment of the lacrimal and salivary glands leading to sicca symptoms. This disease may be classified as primary Sjogren's syndrome (pSS), or secondary Sjogren's syndrome (sSS) since it is often associated to other autoimmune disorders, principally SLE, rheumatoid arthritis, and systemic sclerosis. Systematic reviews and meta-analyses show an sSS prevalence in SLE patients of about 14%-17.8%. Herein, we updated important aspects of the clinical association between SLE and sSS through a narrative review of the PubMed database in the last 5 years (from July 2013 to October 2018) with the terms ``Sjogren syndrome and systemic lupus erythematosus{''}. The following aspects are addressed: the classification criteria for sSS; differences and similarities between SLE and pSS regarding demographic, clinical, and serological characteristics (including new autoantibodies), as well as comorbidities; the etiopathogenic links between SLE and pSS (including genetic and environmental factors, B-cell activation, and autoantibodies); the predictive factors for sSS onset in SLE patients; the ocular and oral involvements due to sSS in SLE; and the main distinctive demographic, clinical, and serological features of SLE with and without associated SS. (AU)

• Processo FAPESP: 18/09937-9 - Análise do perfil imune da saliva e soro dos pacientes com Síndrome de Sjogren primária
• Beneficiário: Victor Adriano de Oliveira Martins
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático