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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Genome Association Study for Visual Scores in Nellore Cattle Measured at Weaning

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Autor(es):
Duitama Carreno, Luis Orlando [1] ; Pessoa, Matilde da Conceicao [1] ; Espigolan, Rafael [1] ; Takada, Luciana [1] ; Bresolin, Tiago [1] ; Cavani, Ligia [1] ; Baldi, Fernando [1] ; Carvalheiro, Roberto [1] ; de Albuquerque, Lucia Galvao [1] ; da Fonseca, Ricardo [2]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ Unesp, Sch Agr & Vet Sci, Anim Sci Dept, Jaboticabal, SP - Brazil
[2] Sao Paulo State Univ Unesp, Anim Sci Dept, Dracena, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: BMC Genomics; v. 20, FEB 20 2019.
Citações Web of Science: 0
Resumo

BackgroundGenome-wide association studies (GWAS) are utilized in cattle to identify regions or genetic variants associated with phenotypes of interest, and thus, to identify design strategies that allow for the increase of the frequency of favorable alleles. Visual scores are important traits of cattle production in Brazil because they are utilized as selection criteria, helping to choose more harmonious animals. Despite its importance, there are still no studies on the genome association for these traits. This study aimed to identify genome regions associated with the traits of conformation, precocity and muscling, based on a visual score measured at weaning.ResultsBayesian approaches with BayesC and Bayesian LASSO were utilized with 2873 phenotypes of Nellore cattle for a GWAS. The animals were genotyped with Illumina BovineHD BeadChip, and a total of 309,865 SNPs were utilized after quality control. In the analyses, phenotype and deregressed breeding values were utilized as dependent variables; a threshold model was utilized for the former and a linear model for the latter. The association criterion was the percentage of genetic variance explained by SNPs found in 1Mb-long windows. The Bayesian approach BayesC was better adjusted to the data because it could explain a larger phenotypic variance for both dependent variables.ConclusionsThere were no large effects for the visual scores, indicating that they have a polygenic nature; however, regions in chromosomes 1, 3, 5, 7, 14, 15, 16, 19, 20 and 23 were identified and explained a large part of the genetic variance. (AU)

Processo FAPESP: 09/16118-5 - Ferramentas genômicas no melhoramento genético de características de importância econômica direta em bovinos da raça Nelore
Beneficiário:Lucia Galvão de Albuquerque
Linha de fomento: Auxílio à Pesquisa - Temático