Dimerizatiori of Antimicrobial Peptides: A Promising Strategy to Enhance Antimicrobial Peptide Activity

Autor(es)

Lorenzon, Esteban N. ^[1] ; Piccoli, Julia P. ^[2] ; Santos-Filho, Norival A. ^[3] ; Cilli, Eduardo M. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Jatai, Unidade Acad Especial Saude, Jatai, GO - Brazil

^[2] UNESP Univ Estadual Paulista, Inst Quim, Araraquara, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Campus Expt Registro, Registro, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: PROTEIN AND PEPTIDE LETTERS; v. 26, n. 2, p. 98-107, 2019.
• Citações Web of Science: 0

Resumo

Antimicrobial resistance is a global health problem with strong social and economic impacts. The development of new antimicrobial agents is considered an urgent challenge. In this regard, Antimicrobial Peptides (AMPs) appear to he novel candidates to overcome this problem. The mechanism of action of AMPs involves intracellular targets and membrane disruption. Although the exact mechanism of action of AMPs remains controversial, most AMPs act through membrane disruption of the target cell. Several strategies have been used to improve AMP activity-, such as peptide dimerization. In this review, we focus on AMP dimerization, showing many examples of dimerized peptides and their effects on biological activity. Although more studies are necessary to elucidate the relationship between peptide properties and the dimerization effect on antimicrobial activity, dimerization constitutes a promising strategy to improve the effectiveness of AMPs. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 12/15346-7 - Peptídeos antimicrobianos: efeito da dimerização e produção de biomembranas de látex/peptídeos
• Beneficiário: Eduardo Maffud Cilli
• Linha de fomento: Auxílio à Pesquisa - Regular