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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Rational design of polymer-lipid nanoparticles for docetaxel delivery

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Autor(es):
Albano, Juan M. R. [1, 2] ; de Morais Ribeiro, Ligia Nunes [3] ; Couto, Veronica Muniz [3] ; Messias, Mariana Barbosa [3] ; Rodrigues da Silva, Gustavo Henrique [3] ; Breitkreitz, Marcia Cristina [4] ; de Paula, Eneida [3] ; Pickholz, Monica [1, 2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fis, Buenos Aires, DF - Argentina
[2] Univ Buenos Aires, CONICET, Inst Fis Buenos Aires IFIBA, Buenos Aires, DF - Argentina
[3] Univ Estadual Campinas, UNICAMP, Inst Biol, Biochem & Tissue Biol Dept, Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Inst Chem, POB 6154, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: COLLOIDS AND SURFACES B-BIOINTERFACES; v. 175, p. 56-64, MAR 1 2019.
Citações Web of Science: 4
Resumo

In this work, a stable nanocarrier for the anti-cancer drug docetaxel was rational designed. The nanocarrier was developed based on the solid lipid nanoparticle preparation process aiming to minimize the total amount of excipients used in the final formulations. A particular interest was put on the effects of the polymers in the final composition. In this direction, two poloxoamers -Pluronic F127 and F68- were selected. Some poloxamers are well known to be inhibitors of the P-glycoprotein efflux pump. Additionally, their poly-ethylene-oxide blocks can help them to escape the immune system, making the poloxamers appealing to be present in a nanoparticle designed for the treatment of cancer. Within this context, a factorial experiment design was used to achieve the most suitable formulations, and also to identify the effects of each component on the final (optimized) systems. Two final formulations were chosen with sizes < 250 nm and PDI < 0.2. Then, using dynamic light scattering and nanotracking techniques, the stability of the formulations was assessed during six months. Structural studies were carried on trough different techniques: DSC, x-ray diffraction, FTIR-AR and Molecular Dynamics. The encapsulation efficiency of the anticancer drug docetaxel (> 90%) and its release dynamics from formulations were measured, showing that the polymer-lipid nanoparticle is suitable as a drug delivery system for the treatment of cancer. (AU)

Processo FAPESP: 14/25372-0 - Desenvolvimento de carreadores lipídicos nanoestruturados para encapsulação de anestésicos locais processados em matrizes biopoliméricas para aplicação tópica em mucosa oral
Beneficiário:Lígia Nunes de Morais Ribeiro
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 14/14457-5 - Carreadores baseados em lipídios (SLN/NLC e lipossomas com gradiente iônico) como estratégia para aumentar a encapsulação e a potência de anestésicos locais
Beneficiário:Eneida de Paula
Linha de fomento: Auxílio à Pesquisa - Temático