Detrimental Impact of Low Birth Weight on Circulating Number and Functional Capacity of Endothelial Progenitor Cells in Healthy Children: Role of Angiogenic Factors

Autor(es)

Souza, Livia Victorino ^[1] ; De Meneck, Franciele ^[1] ; Oliveira, Vanessa ^[1] ; Higa, Elisa Mieko ^[1] ; Akamine, Eliana Hiromi ^[2] ; Franco, Maria do Carmo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Pharmacol Dept, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF PEDIATRICS; v. 206, p. 72+, MAR 2019.
• Citações Web of Science: 3

Resumo

Objective To provide a comprehensive assessment of the relationship of birth weight with both endothelial progenitor cell function and angiogenic factors in children. Study design Anthropometric measures, biochemical profile, endothelial progenitor cell number, endothelial progenitor cell colony-forming units, vascular endothelial growth factor-A, and nitric oxide plasma levels of 58 children aged 7-11 years were determined. Results A positive correlation was observed between birth weight and circulating endothelial progenitor cell number (r = 0.461; P= .001), endothelial progenitor cell colony-forming units (r = 0.512: P < .001), vascular endothelial growth factor-A (r= 0.407; P = .002), and nitric oxide (r = 0.547: P < .001) levels, whereas the adjustment for prematurity, family history of cardiovascular disease, and systolic blood pressure levels did not modify these associations. Conclusion Low birth weight was associated with a decrease in the circulating/functional capacity of endothelial progenitor cells among healthy children, independent of traditional cardiovascular risk factors. This detrimental impact was accompanied by lower circulating levels of angiogenic factors. (AU)

• Processo FAPESP: 13/03139-0 - Inter-relação do peso ao nascer, treinamento físico e níveis pressóricos: uma abordagem clínica e experimental sobre o papel das células progenitoras endoteliais
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular