Luteal vascularity and embryo dynamics in mares during early gestation: Effect of age and endometrial degeneration

Autor(es)

Ferreira, Jair Camargo ^{[1, 2]} ; Boakari, Yatta Linhares ^[1] ; Rocha, Noeme Sousa ^[3] ; Ignacio, Fernanda Saules ^[1] ; da Costa, Guilherme Barbosa ^[2] ; de Meira, Cezinande ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, Botucatu, SP - Brazil

^[2] Univ Franca, Vet Sci Grad Program, Franca - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin, Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTION IN DOMESTIC ANIMALS; v. 54, n. 3, p. 571-579, MAR 2019.
• Citações Web of Science: 0

Resumo

Contents The present study characterized the luteal status and the dynamic of the conceptus during the first 20 days of gestation in mares with different ages and degrees of endometrial degeneration. Total area of the corpus luteum (CL), luteal vascularity, CL area with blood signals, progesterone concentrations (P4), embryonic vesicle diameter, number of embryonic location changes, embryonic fixation position and uterine contractility were evaluated. In Experiment 1, mares <= 6 years of age (Young group, 5.6 +/- 0.2 years, n = 7 mares) and mares >= 15 years of age (Old group, 17.2 +/- 0.9 years, n = 6 mares) were used to investigate the effect of age. In Experiment 2, the luteal and embryonic parameters were compared between mares with minimal (Mild group, endometrial category I, n = 9 mares) and severe (Severe group, endometrial category III, n = 7 mares) endometrial degeneration. The Old and Severe groups had greater (p <= 0.04) total CL area and reduced luteal vascularity (p <= 0.04) than the Young and Mild groups, respectively. However, P4 levels and CL area with blood signals were similar (p >= 0.8) between the groups. A negative effect of age (p < 0.01), but not of endometrial degeneration (p = 0.6), was found for the embryonic vesicle diameter. The conceptus mobility was high (p > 0.1) until day 14 of gestation in the Severe group, while a reduced number of changes of the embryo location was detected earlier (p < 0.05) in the Old group. In conclusion, the newly formed CL of aged mares and mares with severe endometrial degeneration suffered a structural remodelling to safeguard the local blood supply and the continuous P4 output during early gestation. Moreover, an earlier reduction of the embryonic mobility and a delayed development of the conceptus were associated with advanced age, regardless of the degree of endometrial degeneration. (AU)

• Processo FAPESP: 09/52575-1 - Influência das alterações degenerativas endometriais na hemodinâmica do trato reprodutivo de éguas após a inseminação artificial e durante as fases iniciais do desenvolvimento embrionário
• Beneficiário: Jair Camargo Ferreira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 08/54929-2 - Influencia das alteracoes degenerativas endometriais na hemodinamica do trato reprodutivo de eguas apos a inseminacao artificial e durante as fases iniciais do desenvolvimento embrionario.
• Beneficiário: Cezinande de Meira
• Modalidade de apoio: Auxílio à Pesquisa - Regular