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Lipidomic Analysis Reveals Serum Alteration of Plasmalogens in Patients Infected With ZIKA Virus

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Autor(es):
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Queiroz, Adriano [1] ; Dantas Pinto, Isabella Fernanda [2] ; Lima, Maricelia [3] ; Giovanetti, Marta [1, 4] ; de Jesus, Jaqueline Goes [1] ; Xavier, Joilson [1] ; Barreto, Fernanda Khouri [5] ; Baptista Canuto, Gisele Andre [6] ; do Amaral, Helineide Ramos [7] ; Bispo de Filippis, Ana Maria [4] ; Mascarenhas, Denise Lima [8] ; Falcao, Melissa Barreto [8] ; Santos, Normeide Pedreira [8] ; de Carvalho Azevedo, Vasco Ariston [9] ; Yoshinaga, Marcos Yukio [2] ; Miyamoto, Sayuri [2] ; Alcantara, Luiz Carlos Junior [1, 4, 10]
Número total de Autores: 17
Afiliação do(s) autor(es):
[1] Inst Goncalo Moniz, Lab Patol Expt, Salvador, BA - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil
[3] Univ Estadual Feira de Santana, Dept Saude, Feira De Santana - Brazil
[4] Inst Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro - Brazil
[5] Univ Fed Bahia, Inst Multidisciplinar Saude, Vitoria Da Conquista - Brazil
[6] Univ Fed Bahia, Dept Quim Analit, Inst Quim, Salvador, BA - Brazil
[7] Univ Estadual Feira de Santana, Nucleo Pesquisa Vigilancia Saude, Feira De Santana - Brazil
[8] Secretaria Municipal Saude Municipio Feira de San, Feira De Santana - Brazil
[9] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[10] Univ Fed Minas Gerais, Inst Ciencias Biol, Lab Genet Celular & Mol, Belo Horizonte - Brazil
Número total de Afiliações: 10
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN MICROBIOLOGY; v. 10, APR 12 2019.
Citações Web of Science: 0
Resumo

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the Flavivirus genus of the Flaviviridae family. Since the large outbreaks in French Polynesia in 2013-2014 and in Brazil in 2015, ZIKV has been considered a new public health threat. Similar to other related flavivirus, ZIKV is associated with mild and self-limiting symptoms such as rash, pruritus, prostration, headache, arthralgia, myalgia, conjunctivitis, lower back pain and, when present, a short-term low grade fever. In addition, ZIKV has been implicated in neurological complications such as neonatal microcephaly and Guillain-Barre syndrome in adults. Herein, serum lipidomic analysis was used to identify possible alterations in lipid metabolism triggered by ZIKV infection. Patients who presented virus-like symptoms such as fever, arthralgia, headache, exanthema, myalgia and pruritus were selected as the control group. Our study reveals increased levels of several phosphatidylethanolamine (PE) lipid species in the serum of ZIKV patients, the majority of them plasmenyl-phosphatidylethanolamine (pPE) (or plasmalogens) linked to polyunsaturated fatty acids. Constituting up to 20% of total phospholipids in humans, plasmalogens linked to polyunsaturated fatty acids are particularly enriched in neural membranes of the brain. The biosynthesis of plasmalogens requires functional peroxisomes, which are important sites for viral replication, including ZIKV. Thus, increased levels of plasmalogens in serum of ZIKV infected subjects suggest a link between ZIKV life cycle and peroxisomes. Our data provide important insights into specific host cellular lipids that are likely associated with ZIKV replication and may serve as platform for antiviral strategy against ZIKV. (AU)

Processo FAPESP: 13/07937-8 - Redoxoma
Beneficiário:Ohara Augusto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 14/11556-2 - Cardiolipina em doenças neurodegenerativas: caracterização de produtos oxidados e de proteínas modificadas em um modelo de Esclerose Lateral Amiotrófica
Beneficiário:Isabella Fernanda Dantas Pinto
Linha de fomento: Bolsas no Brasil - Doutorado Direto