FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions

Autor(es)

Saulo Gabriel Moreira FALCI ^[1] ; Ana Terezinha Marques MESQUITA ^[2] ; Bruno Augusto Benevenuto de ANDRADE ^[3] ; Joao Luiz de MIRANDA ^[4] ; Jorge Esquiche LEÓN ^[5] ; Oslei Paes de ALMEIDA ^[6] ; Cássio Roberto Rocha dos SANTOS ^[7]

Afiliação do(s) autor(es)

^[1] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil

^[2] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil

^[3] Fluminense Federal University. School of Dentistry - Brasil

^[4] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil

^[5] University of São Paulo. Public Oral Health and Forensic Dentistry. Department of Stomatology - Brasil

^[6] University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil

^[7] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 22, n. 2, p. 131-137, 2014-04-00.

Resumo

Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. (AU)

• Processo FAPESP: 09/53839-2 - Criação do Laboratório de Patologia Digital através do uso do escaneador de lâminas histológicas (Aperio® Scanscope CS)
• Beneficiário: Oslei Paes de Almeida
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários