| Full text | |
| Author(s): |
Saulo Gabriel Moreira FALCI
[1]
;
Ana Terezinha Marques MESQUITA
[2]
;
Bruno Augusto Benevenuto de ANDRADE
[3]
;
Joao Luiz de MIRANDA
[4]
;
Jorge Esquiche LEÓN
[5]
;
Oslei Paes de ALMEIDA
[6]
;
Cássio Roberto Rocha dos SANTOS
[7]
Total Authors: 7
|
| Affiliation: | [1] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil
[2] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil
[3] Fluminense Federal University. School of Dentistry - Brasil
[4] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil
[5] University of São Paulo. Public Oral Health and Forensic Dentistry. Department of Stomatology - Brasil
[6] University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis - Brasil
[7] Federal University of Vales do Jequitinhonha e Mucuri. College of Basic Sciences and Health. Department of Dentistry - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | Journal of Applied Oral Science; v. 22, n. 2, p. 131-137, 2014-04-00. |
| Abstract | |
Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective: To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material and Methods: Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA). Results: Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed. Conclusions: Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. (AU) | |
| FAPESP's process: | 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner |
| Grantee: | Oslei Paes de Almeida |
| Support Opportunities: | Multi-user Equipment Program |