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Creation of a Digital Pathology Laboratory using a histological slidescanner

Grant number: 09/53839-2
Support type:Multi-user Equipment Program
Duration: October 01, 2010 - September 30, 2012
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Oslei Paes de Almeida
Grantee:Oslei Paes de Almeida
Home Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
As informações abaixo são de responsabilidade do Pesquisador responsável.
EMU web page: Página do Equipamento Multiusuário não informada
Tipo de equipamento: Tipo de Equipamento Multiusuário não informado
Fabricante: Fabricante não informado
Modelo: Modelo não informado

Abstract

The major equipment requested is a digital scanner model with a five-slide capacity, each slide being scanned completely in approximately three minutes. The image quality, low noise generation, small file sizes and speed in the process of scanning by columns make this unit unique in the market. We intend to establish a Digital Pathology Laboratory, the infrastructure of which will allow basic research, teaching, consulting and training of human resources. This slide scanner will allow a leap in how pathology research is carried out. By digitizing the images from slides stained with H&E or immunohistochemistry, together with the use of software for ploidy analysis, immunohistochemical quantification of nuclear or cytoplasmic staining, tissue microarray and blood vessel microdensity, the scanner will enable the rapid advancement of knowledge in pathology. The acquisition of this equipment will allow the generation of multi-user scientific works in digital pathology and allow a shift in teaching histology to undergraduate and graduate students at the colleges involved, because image analysis will be faster and images will be more easily stored. The prospect is that the Digital Pathology Laboratory of the UNICAMP Faculty of Dentistry of Piracicaba might soon achieve excellence in providing services to pathology laboratories, nationally and internationally. To that end, 12 professors/ researchers from various national and international colleges gathered and compiled this FAPESP Multi-User Equipment Program request. There are two FAPESP Thematic Projects associated with this request. We would also like to point out that the researchers involved are full professors of the Graduate Program in Oral Pathology/Stomatology at the UNICAMP Faculty of Dentistry of Piracicaba, which is currently the only such program to have received a level 6 grade from the Brazilian National Office for the Advancement of Higher Education (7 being the highest possible grade). (AU)

Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAMACENO ARAUJO, ANNA LUIZA; ARISTIZABAL ARBOLEDA, LADY PAOLA; PALMIER, NATALIA RANGEL; FONSECA, JESSICA MONTENEGRO; PAGLIONI, MARIANA DE PAULI; GOMES-SILVA, WAGNER; PRADO RIBEIRO, ANA CAROLINA; BRANDAO, THAIS BIANCA; SIMONATO, LUCIANA ESTEVAM; SPEIGHT, PAUL M.; FONSECA, FELIPE PAIVA; LOPES, MARCIO AJUDARTE; DE ALMEIDA, OSLEI PAES; VARGAS, PABLO AGUSTIN; MADRID TROCONIS, CRISTHIAN CAMILO; SANTOS-SILVA, ALAN ROGER. The performance of digital microscopy for primary diagnosis in human pathology: a systematic review. Virchows Archiv, v. 474, n. 3, p. 269-287, MAR 2019. Web of Science Citations: 1.
DAMACENO ARAUJO, ANNA LUIZA; AMARAL-SILVA, GLEYSON KLEBER; FONSECA, FELIPE PAIVA; PALMIER, NATALIA RANGEL; LOPES, MARCIO AJUDARTE; SPEIGHT, PAUL M.; DE ALMEIDA, OSLEI PAES; VARGAS, PABLO AGUSTIN; SANTOS-SILVA, ALAN ROGER. Validation of digital microscopy in the histopathological diagnoses of oral diseases. Virchows Archiv, v. 473, n. 3, p. 321-327, SEP 2018. Web of Science Citations: 2.
FONSECA, FELIPE PAIVA; BINGLE, LYNNE; SANTOS-SILVA, ALAN ROGER; LOPES, MARCIO AJUDARTE; COLETTA, RICARDO D.; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; MARIANO, FERNANDA VIVIANE; KOWALSKI, LUIZ PAULO; CARRINHO AYROZA RANGEL, ANA LUCIA; MARTINS, MANOELA DOMINGUES; MEURER, LUISE; HUNTER, KEITH D.; SPEIGHT, PAUL M.; VARGAS, PABLO AGUSTIN. Immunoexpression of hoxb7 and hoxb9 in salivary gland tumours. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 9, p. 672-681, OCT 2016. Web of Science Citations: 0.
FLORES, ISADORA L.; KAWAHARA, REBECA; MIGUEL, MARCIA C. C.; GRANATO, DANIELA C.; DOMINGUES, ROMENIA R.; MACEDO, CAROLINA C. S.; CARNIELLI, CAROLINA M.; YOKOO, SAMI; RODRIGUES, PRISCILA C.; MONTEIRO, BARBARA V. B.; OLIVEIRA, CARINE E.; SALMON, CRISTIANE R.; NOCITI, FRANCISCO H.; LOPES, MARCIO A.; SANTOS-SILVA, ALAN; WINCK, FLAVIA V.; COLETTA, RICARDO D.; PAES LEME, ADRIANA F. EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma. Clinical Science, v. 130, n. 10, p. 785-799, MAY 1 2016. Web of Science Citations: 12.
FONSECA, FELIPE P.; BINGLE, LYNNE; SANTOS-SILVA, ALAN R.; LOPES, MARCIO A.; DE ALMEIDA, OSLEI P.; DE ANDRADE, BRUNO A. B.; MARIANO, FERNANDA V.; KOWALSKI, LUIZ P.; RANGEL, ANA L. C. A.; MARTINS, MANOELA D.; MEURER, LUISE; SPEIGHT, PAUL M.; VARGAS, PABLO A. Semaphorins and neuropilins expression in salivary gland tumors. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 45, n. 2, p. 119-126, FEB 2016. Web of Science Citations: 4.
KAWAHARA, REBECA; MEIRELLES, GABRIELA V.; HEBERLE, HENRY; DOMINGUES, ROMENIA R.; GRANATO, DANIELA C.; YOKOO, SAMI; CANEVAROLO, RAFAEL R.; WINCK, FLAVIAV.; RIBEIRO, ANA CAROLINA P.; BRANDAO, THAIS BIANCA; FILGUEIRAS, PAULO R.; CRUZ, KAREN S. P.; BARBUTO, JOSE ALEXANDRE; POPPI, RONEI J.; MINGHIM, ROSANE; TELLES, GUILHERME P.; FONSECA, FELIPE PAIVA; FOX, JAY W.; SANTOS-SILVA, ALAN R.; COLETTA, RICARDO D.; SHERMAN, NICHOLAS E.; PAES LEME, ADRIANA F. Integrative analysis to select cancer candidate biomarkers to targeted validation. ONCOTARGET, v. 6, n. 41, p. 43635-43652, DEC 22 2015. Web of Science Citations: 6.
FONSECA, FELIPE PAIVA; MONTANHANA BASSO, MARCOS PAULO; MARIANO, FERNANDA VIVIANE; KOWALSKI, LUIZ PAULO; LOPES, MARCIO AJUDARTE; MARTINS, MANOELA DOMINGUES; CARRINHO AYROZA RANGEL, ANA LUCIA; SANTOS-SILVA, ALAN ROGER; VARGAS, PABLO AGUSTIN. Vascular endothelial growth factor immunoexpression is increased in malignant salivary gland tumors. ANNALS OF DIAGNOSTIC PATHOLOGY, v. 19, n. 3, p. 169-174, JUN 2015. Web of Science Citations: 4.
FONSECA, FELIPE-PAIVA; SANTOS-SILVA, ALAN-ROGER; LOPES, MARCIO-AJUDARTE; DE ALMEIDA, OSLEI-PAES; VARGAS, PABLO-AGUSTIN. Transition from glass to digital slide microscopy in the teaching of oral pathology in a Brazilian dental school. MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, v. 20, n. 1, p. E17-E22, JAN 2015. Web of Science Citations: 8.
GRANATO, DANIELA C.; ZANETTI, MARIANA R.; KAWAHARA, REBECA; YOKOO, SAMI; DOMINGUES, ROMENIA R.; ARAGAO, ANNELIZE Z.; AGOSTINI, MICHELLE; CARAZZOLLE, MARCELO F.; VIDAL, RAMON O.; FLORES, ISADORA L.; KORVALA, JOHANNA; CERVIGNE, NILVA K.; SILVA, ALAN R. S.; COLETTA, RICARDO D.; GRANER, EDGARD; SHERMAN, NICHOLAS E.; PAES LEME, ADRIANA F. Integrated Proteomics Identified Up-Regulated Focal Adhesion-Mediated Proteins in Human Squamous Cell Carcinoma in an Orthotopic Murine Model. PLoS One, v. 9, n. 5 MAY 23 2014. Web of Science Citations: 5.
KAWAHARA, REBECA; LIMA, RENATO NIYAMA; DOMINGUES, ROMENIA R.; PAULETTI, BIANCA ALVES; MEIRELLES, GABRIELA V.; ASSIS, MICHELLE; MIGLIORINI FIGUEIRA, ANA CAROLINA; PAES LEME, ADRIANA FRANCO. Deciphering the Role of the ADAM17-Dependent Secretome in Cell Signaling. JOURNAL OF PROTEOME RESEARCH, v. 13, n. 4, p. 2080-2093, APR 2014. Web of Science Citations: 20.
BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; RAMIREZ-AMADOR, VELIA; ANAYA-SAAVEDRA, GABRIELA; MARTINEZ-MATA, GUILLERMO; FONSECA, FELIPE P.; GRANER, EDGARD; DE ALMEIDA, OSLEI PAES. Expression of PROX-1 in oral Kaposi's sarcoma spindle cells. JOURNAL OF ORAL PATHOLOGY & MEDICINE, v. 43, n. 2, p. 132-136, FEB 2014. Web of Science Citations: 3.
FONSECA, FELIPE PAIVA; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; CARRINHO AYROSA RANGEL, ANA LUCIA; DELLA COLETTA, RICARDO; LOPES, MARCIO AJUDARTE; DE ALMEIDA, OSLEI PAES; VARGAS, PABLO AGUSTIN. Tissue microarray is a reliable method for immunohistochemical analysis of pleomorphic adenoma. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 117, n. 1, p. 81-88, JAN 2014. Web of Science Citations: 22.
SAULO GABRIEL MOREIRA FALCI; ANA TEREZINHA MARQUES MESQUITA; BRUNO AUGUSTO BENEVENUTO DE ANDRADE; JOAO LUIZ DE MIRANDA; JORGE ESQUICHE LEÓN; OSLEI PAES DE ALMEIDA; CÁSSIO ROBERTO ROCHA DOS SANTOS. FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions. Journal of Applied Oral Science, v. 22, n. 2, p. -, Abr. 2014.
RIVERA, CESAR; GONZALEZ-ARRIAGADA, WILFREDO A.; LOYOLA-BRAMBILLA, MARCO; DE ALMEIDA, OSLEL PAES; DELLA COLETTA, RICARDO; VENEGAS, BERNARDO. Clinicopathological and immunohistochemical evaluation of oral and oropharyngeal squamous cell carcinoma in Chilean population. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, v. 7, n. 9, p. 5968-5977, 2014. Web of Science Citations: 4.
FONSECA, FELIPE PAIVA; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; COLETTA, RICARDO D.; VARGAS, PABLO AGUSTIN; LOPES, MARCIO AJUDARTE; DE ALMEIDA, OSLEI PAES; SANTOS-SILVA, ALAN ROGER. Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 115, n. 4, p. 532-540, APR 2013. Web of Science Citations: 5.
FONSECA, FELIPE PAIVA; BENEVENUTO DE ANDRADE, BRUNO AUGUSTO; LOPES, MARCIO AJUDARTE; REBELO PONTES, HELDER ANTONIO; VARGAS, PABLO AGUSTIN; DE ALMEIDA, OSLEI PAES. P63 expression in papillary cystadenoma and mucoepidermoid carcinoma of minor salivary glands. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 115, n. 1, p. 79-86, JAN 2013. Web of Science Citations: 11.
PAIVA-FONSECA, FELIPE; DE-ALMEIDA, OSLEI-PAES; AYROZA-RANGEL, ANA-LUCIA-CARRINHO; AGUSTIN-VARGAS, PABLO. Tissue microarray construction for salivary gland tumors study. MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, v. 18, n. 1, p. E1-E6, JAN 2013. Web of Science Citations: 7.
PRADO RIBEIRO, ANA CAROLINA; CARLOS, ROMAN; SPEIGHT, PAUL M.; HUNTER, KEITH D.; SANTOS-SILVA, ALAN ROGER; DE ALMEIDA, OSLEI PAES; VARGAS, PABLO AGUSTIN. Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 114, n. 4, p. 503-508, OCT 2012. Web of Science Citations: 9.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.