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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma

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Flores, Isadora L. [1, 2] ; Kawahara, Rebeca [1] ; Miguel, Marcia C. C. [2, 3] ; Granato, Daniela C. [1] ; Domingues, Romenia R. [1] ; Macedo, Carolina C. S. [1, 2] ; Carnielli, Carolina M. [1] ; Yokoo, Sami [1] ; Rodrigues, Priscila C. [2] ; Monteiro, Barbara V. B. [2, 3] ; Oliveira, Carine E. [2] ; Salmon, Cristiane R. [4] ; Nociti, Francisco H. [4] ; Lopes, Marcio A. [2] ; Santos-Silva, Alan [2] ; Winck, Flavia V. [1] ; Coletta, Ricardo D. [2] ; Paes Leme, Adriana F. [1]
Total Authors: 18
[1] CNPEM, LNBio, Lab Nacl Biociencias, Lab Espectrometria Massas, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Odontol Piracicaba, Dept Diagnost Oral, Piracicaba, SP - Brazil
[3] Univ Fed Rio Grande do Norte, Dept Odontol, BR-59072970 Natal, RN - Brazil
[4] Univ Estadual Campinas, UNICAMP, Fac Odontol Piracicaba, Dept Protese & Periodontia, Piracicaba, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Clinical Science; v. 130, n. 10, p. 785-799, MAY 1 2016.
Web of Science Citations: 14

EEF1D (eukaryotic translation elongation factor 1 delta) is a subunit of the elongation factor 1 complex of proteins that mediates the elongation process during protein synthesis via enzymatic delivery of aminoacyl-tRNAs to the ribosome. Although the functions of EEF1D in the translation process are recognized, EEF1D expression was found to be unbalanced in tumours. In the present study, we demonstrate the overexpression of EEF1D in OSCC (oral squamous cell carcinoma), and revealed that EEF1D and protein interaction partners promote the activation of cyclin D1 and vimentin proteins. EEF1D knockdown in OSCC reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes, including cell invasion. Taken together, these results define EEF1D as a critical inducer of OSCC proliferation and EMT. (AU)

FAPESP's process: 13/01607-6 - The biological role of EEF1D, fascin and plectin on oral squamous cell carcinoma
Grantee:Ricardo Della Coletta
Support type: Regular Research Grants
FAPESP's process: 09/54067-3 - Acquisition of a mass spectrometer coupled to a liquid chromatography system for increasing the capacity to meet the needs of users and for making new technologies available in the Laboratory of Mass Spectrometry
Grantee:Adriana Franco Paes Leme
Support type: Multi-user Equipment Program
FAPESP's process: 11/22421-2 - Determination of cleavage sites of recombinant ADAM-17 in human cells
Grantee:Rebeca Kawahara Sakuma
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 10/19278-0 - Study of regulation of ADAMs in oral cancer
Grantee:Adriana Franco Paes Leme
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner
Grantee:Oslei Paes de Almeida
Support type: Multi-user Equipment Program