GAB(A) but not GABA(B) receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in rats

Autor(es)

Gomes-de-Souza, Lucas ^{[1, 2]} ; Benini, Ricardo ^{[1, 2]} ; Costa-Ferreira, Willian ^{[1, 2]} ; Crestani, Carlos C. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Joint UFSCar UNESP Grad Program Physiol Sci, Sao Carlos, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Pharmacol Lab, Rodovia Araraquara Jau Km 01, Campus Univ, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: European Neuropsychopharmacology; v. 29, n. 5, p. 672-680, MAY 2019.
• Citações Web of Science: 0

Resumo

The lateral hypothalamus (LH) has been described as one of the hypothalamic areas involved in the behavioral and physiological responses triggered by aversive stimuli. Previous studies indicated involvement of the LH in cardiovascular responses to stress. Despite this evidence, the local neurochemical mechanisms involved in LH control of stress responses is still poorly understood. Therefore, in the present study, we investigated the role of GABAergic neurotransmission within the LH in cardiovascular responses induced by an acute session of restraint stress in rats. For this, we evaluated the effect of bilateral microinjection of selective antagonists of either GABA A or GABA B receptors into the LH on arterial pressure increase, heart rate (HR) increase and reduction in tail skin temperature induced by restraint stress. We found that microinjection of the selective GABA A receptor antagonist SR95531 into the LH decreased the increase in HR caused by restraint stress, but without affecting the increase in arterial pressure increase or the reduction in tail skin temperature. Conversely, LH treatment with the selective GABA B receptor antagonist CGP35348 did not affect the restraint-evoked cardiovascular changes. These findings indicate that GABAergic neurotransmission in the LH, acting through activation of local GABA A receptors, plays a facilitatory role in the tachycardic response observed during aversive threats. (c) 2019 Elsevier B.V. and ECNP. All rights reserved. (AU)

• Processo FAPESP: 15/05922-9 - Estudo da participação da neurotransmissão CRFérgica do núcleo leito da estria terminal nas alterações cardiovasculares induzidas pelo estresse: interação com a via de sinalização receptor NMDA / óxido nítrico/guanilato ciclase / proteína quinase g?
• Beneficiário: Carlos Cesar Crestani
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/19249-0 - Envolvimento de neurotransmissões angiotensinérgicas do núcleo medial da amígdala no controle das respostas cardiovasculares e ansiogênica ao estresse em ratos
• Beneficiário: Carlos Cesar Crestani
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/05028-9 - Controle das respostas cardiovasculares ao estresse pela neurotransmissão endocanabinóide no núcleo leito da estria terminal em ratos: interação com a via de sinalização receptor NMDA/NO/GMPc/proteína quinase g e envolvimento do hipotálamo lateral
• Beneficiário: Lucas Gomes de Souza
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/05218-2 - Envolvimento das sinalizações angiotensina II/receptor AT1 e angiotensina 1-7/ receptor Mas no núcleo medial da amígdala nas respostas cardiovasculares e ansiogênica ao estresse em ratos
• Beneficiário: Willian Costa Ferreira
• Linha de fomento: Bolsas no Brasil - Doutorado