Abnormalities in the evoked frontal oscillatory activity of first-episode psychosis: A TMS/EEG study

Autor(es)

Ferrarelli, Fabio ^[1] ; Kaskie, Rachel E. ^[1] ; Graziano, Bianca ^[1] ; Reis, Catarina Cardoso ^[2] ; Casali, Adenauer G. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Pittsburgh, Dept Psychiat, 3501 Forbes Ave, Pittsburgh, PA 15213 - USA

^[2] Univ Fed Sao Paulo, Inst Sci & Technol, Sao Jose Dos Campos - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 206, p. 436-439, APR 2019.
• Citações Web of Science: 2

Resumo

TMS with simultaneous EEG allows assessing the intrinsic oscillatory activity of cortical neurons. We recently showed reduced frontal cortical oscillations in chronic schizophrenia (SCZ). Here we investigated the oscillatory activity of first-episode psychosis (FEP) patients after TMS of a frontal area, the motor cortex. Compared to healthy controls, FEP patients had significantly reduced beta/low gamma oscillations, which were associated to worse clinical symptoms. Altogether, this study demonstrates that TMS/EEG recordings: 1) are feasible in acute, early-course psychotic patients; and 2) reveal intrinsic oscillatory deficits at illness onset, which may help design more effective, early interventions in SCZ. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 16/08263-9 - Padronização, validação e caracterização de uma nova medida de complexidade cerebral
• Beneficiário: Adenauer Girardi Casali
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/20422-5 - Análise tempo-freqüência de oscilações corticais evocadas pela estimulação magnética transcraniana em fases pré-clínicas da esquizofrenia
• Beneficiário: Catarina Cardoso Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica