Abnormalities in the evoked frontal oscillatory activity of first-episode psychosis: A TMS/EEG study

Author(s)

Ferrarelli, Fabio ^[1] ; Kaskie, Rachel E. ^[1] ; Graziano, Bianca ^[1] ; Reis, Catarina Cardoso ^[2] ; Casali, Adenauer G. ^[2]

Affiliation

^[1] Univ Pittsburgh, Dept Psychiat, 3501 Forbes Ave, Pittsburgh, PA 15213 - USA

^[2] Univ Fed Sao Paulo, Inst Sci & Technol, Sao Jose Dos Campos - Brazil

• Document type: Journal article
• Source: SCHIZOPHRENIA RESEARCH; v. 206, p. 436-439, APR 2019.
• Web of Science Citations: 2

Abstract

TMS with simultaneous EEG allows assessing the intrinsic oscillatory activity of cortical neurons. We recently showed reduced frontal cortical oscillations in chronic schizophrenia (SCZ). Here we investigated the oscillatory activity of first-episode psychosis (FEP) patients after TMS of a frontal area, the motor cortex. Compared to healthy controls, FEP patients had significantly reduced beta/low gamma oscillations, which were associated to worse clinical symptoms. Altogether, this study demonstrates that TMS/EEG recordings: 1) are feasible in acute, early-course psychotic patients; and 2) reveal intrinsic oscillatory deficits at illness onset, which may help design more effective, early interventions in SCZ. (C) 2018 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 16/08263-9 - Standardization, validation and characterization of a novel index of brain complexity
• Grantee: Adenauer Girardi Casali
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/20422-5 - Time-frequency analysis of cortical oscillations evoked by transcranial magnetic stimulation in preclinical stages of schizophrenia
• Grantee: Catarina Cardoso Reis
• Support Opportunities: Scholarships in Brazil - Scientific Initiation