| Texto completo | |
| Autor(es): |
dos Santos, Monica Pezenatto
[1]
;
Sallas, Mayara Luciana
[1]
;
Zapparoli, Diana
[1]
;
Orcini, Wilson Aparecido
[1]
;
Chen, Elizabeth
[2]
;
Cardoso Smith, Marilia de Arruda
[2]
;
Marques Payao, Spencer L.
[3]
;
Rasmussen, Lucas Trevizani
[3, 1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] USC, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil
[3] Fac Med Marilia FAMEMA, Hemoctr, Sao Paulo - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Cellular Biochemistry; v. 120, n. 6, p. 9448-9454, JUN 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
The process of combating neoplasms and mononuclear cells, and during H. pylori infection, several pro-inflammatory and anti-inflammatory cytokines are synthesized. In view of the involvement of the IL-6 law and the presence of H. pylori in the development of gastric diseases, the present study aimed to characterize the promoter-region polymorphism -597 (G/A) (rs1800797), -572 (C/G) (rs1800796), and -174 (G/C) (rs1800795) by PCR-RFLP in 375 gastric biopsy specimens from patients with peptic symptoms. A total of 375 samples were analyzed: 87 patients (without lesion without gastric tissue); 236 patients with gastritis and 52 patients with gastric cancer analyzed the PCR-RFLP techniques. All the results were normalized in relation to the presence of H. pylori. The frequencies of the three polymorphisms were compared in the Control vs Gastritis groups and a statistically significant test observed: -174 (G/C) (OR: 1.27; 95% CI: 0.84-1.93; P=0.26), 572 (C/G) (OR: 1.42; 95% CI: 0.78-2.59; P=0.25), and 597 (G/A) (OR: 0.98; 95% CI, 0.64-1.52; P=0.94). Similar results were obtained when the gastric cancer group was compared to the control group: -174 (G/C) (OR: 1.27; 95% CI: 0.66-2.47; P=0.47), -572 (C/G) (OR: 1.07; 95% CI: 0.43-2.68; P=0.88), and -597 (G/A) (OR: 1.01; 95% CI, 0.5-0.9; P=0.99). The haplotypes were and were not observed statistically significant differences. In conclusion, we found no correlations between any of the three polymorphisms in the IL-6 gene analyzed in this study and a higher risk of gastritis or gastric cancer. (AU) | |
| Processo FAPESP: | 18/08481-1 - Análise da Interação Gênica e Proteica entre Componentes das Vias Inflamatória, da Apoptose e MicroRNAs em Doença Dispéptica e Câncer Gástrico |
| Beneficiário: | Lucas Trevizani Rasmussen |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/11371-5 - Análise da Expressão de Micro RNAs e de Genes Associados a Apoptose e a Inflamação nas Doenças Gástricas: Uma Possível Relação com o Helicobacter pylori |
| Beneficiário: | Lucas Trevizani Rasmussen |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |