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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

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Autor(es):
Arantes Bueno, Ana Paula [1, 2] ; Lopez Pinaya, Walter Hugo [1, 3] ; Rebello, Keila [1] ; de Souza, Leonardo Cruz [4] ; Hornberger, Michael [2, 5] ; Sato, Joao Ricardo [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre - Brazil
[2] Univ East Anglia, Norwich Med Sch, Dept Med, Norwich, Norfolk - England
[3] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London - England
[4] Univ Fed Minas Gerais, Dept Internal Med, Belo Horizonte, MG - Brazil
[5] Norfolk & Suffolk NHS Fdn Trust, Norwich, Norfolk - England
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BRAIN CONNECTIVITY; v. 9, n. 4, p. 356-364, MAY 1 2019.
Citações Web of Science: 1
Resumo

Resting-state functional magnetic resonance imaging has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of nondemented ALS patients compared with healthy controls. As expected, we found the sensorimotor network with changes in fALFF and ReHo, and also found the default mode network (DMN), frontoparietal network (FPN), and salience network (SN) altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low-frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of nonmotor regions, including those responsible for cognition. (AU)

Processo FAPESP: 16/19376-9 - Integridade estrutural e funcional do circuito de Papez e sua relação com a simtomatologia na Esclerose Lateral Amiotrófica
Beneficiário:Ana Paula Arantes de Andrade Bueno
Linha de fomento: Bolsas no Brasil - Doutorado