| Texto completo | |
| Autor(es): |
Kopacz, Malgorzata M.
[1, 2]
;
Lorenzoni, Andre S. G.
[1]
;
Polaquini, Carlos R.
[3]
;
Regasini, Luis O.
[3]
;
Scheffers, Dirk-Jan
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, Groningen - Netherlands
[2] Univ Southern Denmark, Dept Chem Engn Biotechnol & Environm Technol, Odense M - Denmark
[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Antibiot & Chemotherapeut, Sao Jose Do Rio Preto, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MICROBIOLOGYOPEN; v. 8, n. 5 MAY 2019. |
| Citações Web of Science: | 1 |
| Resumo | |
Xanthomonas citri subsp. citri (Xac) is the causative agent of citrus canker, a plant disease that significantly impacts citriculture. In earlier work, we showed that alkylated derivatives of gallic acid have antibacterial action against Xac and target both the cell division protein FtsZ and membrane integrity in Bacillus subtilis. Here, we have purified native XacFtsZ and characterized its GTP hydrolysis and polymerization properties. In a surprising manner, inhibition of XacFtsZ activity by alkyl gallates is not as strong as observed earlier with B. subtilis FtsZ. As the alkyl gallates efficiently permeabilize Xac membranes, we propose that this is the primary mode of antibacterial action of these compounds. (AU) | |
| Processo FAPESP: | 13/50367-8 - New environmental-friendly compounds to combat Citrus canker |
| Beneficiário: | Henrique Ferreira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 14/18330-0 - Preparação e avaliação biológica de híbridos curcumina-cinamaldeído como inibidores da divisão celular bacteriana |
| Beneficiário: | Luis Octávio Regasini |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |