| Full text | |
| Author(s): |
Kopacz, Malgorzata M.
[1, 2]
;
Lorenzoni, Andre S. G.
[1]
;
Polaquini, Carlos R.
[3]
;
Regasini, Luis O.
[3]
;
Scheffers, Dirk-Jan
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, Groningen - Netherlands
[2] Univ Southern Denmark, Dept Chem Engn Biotechnol & Environm Technol, Odense M - Denmark
[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, Lab Antibiot & Chemotherapeut, Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | MICROBIOLOGYOPEN; v. 8, n. 5 MAY 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Xanthomonas citri subsp. citri (Xac) is the causative agent of citrus canker, a plant disease that significantly impacts citriculture. In earlier work, we showed that alkylated derivatives of gallic acid have antibacterial action against Xac and target both the cell division protein FtsZ and membrane integrity in Bacillus subtilis. Here, we have purified native XacFtsZ and characterized its GTP hydrolysis and polymerization properties. In a surprising manner, inhibition of XacFtsZ activity by alkyl gallates is not as strong as observed earlier with B. subtilis FtsZ. As the alkyl gallates efficiently permeabilize Xac membranes, we propose that this is the primary mode of antibacterial action of these compounds. (AU) | |
| FAPESP's process: | 13/50367-8 - New environmental-friendly compounds to combat citrus canker |
| Grantee: | Henrique Ferreira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/18330-0 - Synthesis and biological evaluation of curcumin-cinnamaldehyde hybrids as bacterial cell division inhibitors |
| Grantee: | Luis Octávio Regasini |
| Support Opportunities: | Regular Research Grants |