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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

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Autor(es):
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Sakata, Dousatsu [1] ; Lampe, Nathanael [2, 3] ; Karamitros, Mathieu ; Kyriakou, Ioanna [4] ; Belov, Oleg [5] ; Bernal, Mario A. [6] ; Bolst, David [1] ; Bordage, Marie-Claude [7, 8] ; Breton, Vincent [9] ; Brown, Jeremy M. C. [10] ; Francis, Ziad [11] ; Ivanchenko, Vladimir [12, 13] ; Meylan, Sylvain [14, 15] ; Murakami, Koichi [16] ; Okada, Shogo [16] ; Petrovic, Ivan [17] ; Ristic-Fira, Aleksandra [17] ; Santin, Giovanni [18] ; Sarramia, David [9] ; Sasaki, Takashi [16] ; Shin, Wook-Geun [2, 3] ; Tang, Nicolas [14] ; Tran, Hoang N. [19, 20] ; Villagrasa, Carmen [14] ; Emfietzoglou, Dimitris [4] ; Nieminen, Petteri [18] ; Guatelli, Susanna [1] ; Incerti, Sebastien [2, 3]
Número total de Autores: 28
Afiliação do(s) autor(es):
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[1] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW - Australia
[2] CNRS, IN2P3, CENBG, UMR 5797, Gradignan - France
[3] Univ Bordeaux, CENBG, UMR 5797, Gradignan - France
[4] Univ Ioannina, Med Phys Lab, Med Sch, GR-45110 Ioannina - Greece
[5] Joint Inst Nucl Res, Dubna - Russia
[6] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil
[7] Univ Paul Sabatier, INSERM, UMR 1037, CRCT, Toulouse - France
[8] Univ Toulouse III Paul Sabatier, UMR 1037, CRCT, Toulouse - France
[9] Univ Clermont Auvergne, CNRS IN2P3, LPC, F-63000 Clermont Ferrand - France
[10] Delft Univ Technol, Radiat Sci & Technol, Delft - Netherlands
[11] Univ St Joseph, Dept Phys, Fac Sci, Beirut - Lebanon
[12] Tomsk State Univ, Tomsk - Russia
[13] Geant4 Associates Int L4, Hebden Bridge - England
[14] IRSN, F-92262 Fontenay Aux Roses - France
[15] SymAlgo Technol, Paris - France
[16] KEK, Tsukuba, Ibaraki - Japan
[17] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade - Serbia
[18] ESA ESTEC, Noordwijk - Netherlands
[19] Ton Duc Thang Univ, Div Nucl Phys, Adv Inst Mat Sci, Ho Chi Mirth City - Vietnam
[20] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City - Vietnam
Número total de Afiliações: 20
Tipo de documento: Artigo Científico
Fonte: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 62, p. 152-157, JUN 2019.
Citações Web of Science: 1
Resumo

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. (AU)

Processo FAPESP: 11/51594-2 - Desenvolvimento de um sistema computacional para a simulação da interação da radiação ionizante com o material genético humano
Beneficiário:Mario Antonio Bernal Rodriguez
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 15/21873-8 - Desenvolvimento e implementação de metodologias para otimização de técnicas de imagens em radiologia digital
Beneficiário:Alessandra Tomal
Linha de fomento: Auxílio à Pesquisa - Regular