Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

Author(s):Show less -

Sakata, Dousatsu ^[1] ; Lampe, Nathanael ^{[2, 3]} ; Karamitros, Mathieu ; Kyriakou, Ioanna ^[4] ; Belov, Oleg ^[5] ; Bernal, Mario A. ^[6] ; Bolst, David ^[1] ; Bordage, Marie-Claude ^{[7, 8]} ; Breton, Vincent ^[9] ; Brown, Jeremy M. C. ^[10] ; Francis, Ziad ^[11] ; Ivanchenko, Vladimir ^{[12, 13]} ; Meylan, Sylvain ^{[14, 15]} ; Murakami, Koichi ^[16] ; Okada, Shogo ^[16] ; Petrovic, Ivan ^[17] ; Ristic-Fira, Aleksandra ^[17] ; Santin, Giovanni ^[18] ; Sarramia, David ^[9] ; Sasaki, Takashi ^[16] ; Shin, Wook-Geun ^{[2, 3]} ; Tang, Nicolas ^[14] ; Tran, Hoang N. ^{[19, 20]} ; Villagrasa, Carmen ^[14] ; Emfietzoglou, Dimitris ^[4] ; Nieminen, Petteri ^[18] ; Guatelli, Susanna ^[1] ; Incerti, Sebastien ^{[2, 3]}

Affiliation:Show less -

^[1] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW - Australia

^[2] CNRS, IN2P3, CENBG, UMR 5797, Gradignan - France

^[3] Univ Bordeaux, CENBG, UMR 5797, Gradignan - France

^[4] Univ Ioannina, Med Phys Lab, Med Sch, GR-45110 Ioannina - Greece

^[5] Joint Inst Nucl Res, Dubna - Russia

^[6] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil

^[7] Univ Paul Sabatier, INSERM, UMR 1037, CRCT, Toulouse - France

^[8] Univ Toulouse III Paul Sabatier, UMR 1037, CRCT, Toulouse - France

^[9] Univ Clermont Auvergne, CNRS IN2P3, LPC, F-63000 Clermont Ferrand - France

^[10] Delft Univ Technol, Radiat Sci & Technol, Delft - Netherlands

^[11] Univ St Joseph, Dept Phys, Fac Sci, Beirut - Lebanon

^[12] Tomsk State Univ, Tomsk - Russia

^[13] Geant4 Associates Int L4, Hebden Bridge - England

^[14] IRSN, F-92262 Fontenay Aux Roses - France

^[15] SymAlgo Technol, Paris - France

^[16] KEK, Tsukuba, Ibaraki - Japan

^[17] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade - Serbia

^[18] ESA ESTEC, Noordwijk - Netherlands

^[19] Ton Duc Thang Univ, Div Nucl Phys, Adv Inst Mat Sci, Ho Chi Mirth City - Vietnam

^[20] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City - Vietnam

• Document type: Journal article
• Source: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 62, p. 152-157, JUN 2019.
• Web of Science Citations: 1

Abstract

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. (AU)

• FAPESP's process: 15/21873-8 - Establishment and application of methodologies for optimizing imaging techniques in digital radiology
• Grantee: Alessandra Tomal
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material
• Grantee: Mario Antonio Bernal Rodriguez
• Support Opportunities: Research Grants - Young Investigators Grants