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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

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Author(s):
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Sakata, Dousatsu [1] ; Lampe, Nathanael [2, 3] ; Karamitros, Mathieu ; Kyriakou, Ioanna [4] ; Belov, Oleg [5] ; Bernal, Mario A. [6] ; Bolst, David [1] ; Bordage, Marie-Claude [7, 8] ; Breton, Vincent [9] ; Brown, Jeremy M. C. [10] ; Francis, Ziad [11] ; Ivanchenko, Vladimir [12, 13] ; Meylan, Sylvain [14, 15] ; Murakami, Koichi [16] ; Okada, Shogo [16] ; Petrovic, Ivan [17] ; Ristic-Fira, Aleksandra [17] ; Santin, Giovanni [18] ; Sarramia, David [9] ; Sasaki, Takashi [16] ; Shin, Wook-Geun [2, 3] ; Tang, Nicolas [14] ; Tran, Hoang N. [19, 20] ; Villagrasa, Carmen [14] ; Emfietzoglou, Dimitris [4] ; Nieminen, Petteri [18] ; Guatelli, Susanna [1] ; Incerti, Sebastien [2, 3]
Total Authors: 28
Affiliation:
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[1] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW - Australia
[2] CNRS, IN2P3, CENBG, UMR 5797, Gradignan - France
[3] Univ Bordeaux, CENBG, UMR 5797, Gradignan - France
[4] Univ Ioannina, Med Phys Lab, Med Sch, GR-45110 Ioannina - Greece
[5] Joint Inst Nucl Res, Dubna - Russia
[6] Univ Estadual Campinas, Inst Fis Gleb Wataghin, Campinas, SP - Brazil
[7] Univ Paul Sabatier, INSERM, UMR 1037, CRCT, Toulouse - France
[8] Univ Toulouse III Paul Sabatier, UMR 1037, CRCT, Toulouse - France
[9] Univ Clermont Auvergne, CNRS IN2P3, LPC, F-63000 Clermont Ferrand - France
[10] Delft Univ Technol, Radiat Sci & Technol, Delft - Netherlands
[11] Univ St Joseph, Dept Phys, Fac Sci, Beirut - Lebanon
[12] Tomsk State Univ, Tomsk - Russia
[13] Geant4 Associates Int L4, Hebden Bridge - England
[14] IRSN, F-92262 Fontenay Aux Roses - France
[15] SymAlgo Technol, Paris - France
[16] KEK, Tsukuba, Ibaraki - Japan
[17] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade - Serbia
[18] ESA ESTEC, Noordwijk - Netherlands
[19] Ton Duc Thang Univ, Div Nucl Phys, Adv Inst Mat Sci, Ho Chi Mirth City - Vietnam
[20] Ton Duc Thang Univ, Fac Appl Sci, Ho Chi Minh City - Vietnam
Total Affiliations: 20
Document type: Journal article
Source: PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS; v. 62, p. 152-157, JUN 2019.
Web of Science Citations: 1
Abstract

The advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%. (AU)

FAPESP's process: 11/51594-2 - Development of a computational system for the simulation of the interaction of ionizing radiations with the human genetic material
Grantee:Mario Antonio Bernal Rodriguez
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 15/21873-8 - Establishment and application of methodologies for optimizing imaging techniques in digital radiology
Grantee:Alessandra Tomal
Support type: Regular Research Grants