Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet

Autor(es)

Santamarina, Aline Boveto ^[1] ; Jamar, Giovana ^[1] ; Mennitti, Lais Vales ^[1] ; Ribeiro, Daniel Araki ^[2] ; Cardoso, Caroline Margonato ^[1] ; de Rosso, Veridiana Vera ^[2] ; Oyama, Lila Missae ^[3] ; Pisani, Luciana Pellegrini ^{[2, 4]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-11015020 Santos - Brazil

^[2] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Santos - Brazil

^[3] Univ Fed Sao Paulo, Dept Fisiol, BR-04023062 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Lab Nutr & Fisiol Endocrina LaNFE, Dept Biociencias, Inst Saude & Soc, Rua Silva Jardim 136, BR-11015020 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 24, n. 9 MAY 1 2019.
• Citações Web of Science: 0

Resumo

Jucara berry is a potential inflammatory modulator, rich in dietary fiber, fatty acids, and anthocyanins. Considering this, we evaluated the high-fat diet (HFD) intake supplemented with different doses of freeze-dried jucara pulp on the TLR4 pathway. Twenty-seven male Wistar rats with ad libitum access to food and water were divided into four experimental groups: control standard chow group (C); high-fat diet control group (HFC); high-fat diet jucara 0.25% group (HFJ0.25%); and high-fat diet jucara 0.5% group (HFJ0.5%). The inflammatory parameters were analyzed by ELISA and Western blotting in liver and retroperitoneal adipose tissue (RET). The HFJ0.25% group had the energy intake, aspartate transaminase (AST) levels, and liver triacylglycerol accumulation reduced; also, the tumor necrosis factor (TNF-) and TNF receptor-associated factor 6 (TRAF6) expression in RET were reduced. However, there were no changes in other protein expressions in liver and adipose tissue. Adiposity and pNFBp50 had a positive correlation in HFC and HFJ0.5%, but not in the C group and HFJ0.25%. The necrosis hepatic score did not change with treatment; however, the serum (AST) levels and the hepatic triacylglycerol were increased in HFC and HFJ0.5%. These results demonstrated that one week of HFD intake triggered pro-inflammatory mechanisms and liver injury. Additionally, 0.25% jucara prevented inflammatory pathway activation, body weight gain, and liver damage (AU)

• Processo FAPESP: 18/23623-7 - Efeito da suplementação de ácido oléico e cianidinas em macrófagos na modulação de processos inflamatórios
• Beneficiário: Aline Boveto Santamarina
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 15/13875-0 - EFEITO DA SUPLEMENTAÇÃO DO FRUTO DA PALMEIRA JUÇARA (Euterpe edulis Mart.) NAS MODIFICAÇÕES EPIGENÉTICAS E ESTADO INFLAMATÓRIO EM MONÓCITOS DE ADULTOS OBESOS
• Beneficiário: Aline Boveto Santamarina
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 16/14133-0 - Mecanismos intracelulares envolvidos com o processo inflamatório em indivíduos obesos antes e após a suplementação de polpa de juçara (Euterpe edulis Mart.)
• Beneficiário: Luciana Pellegrini Pisani
• Modalidade de apoio: Auxílio à Pesquisa - Regular