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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet

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Autor(es):
Santamarina, Aline Boveto [1] ; Jamar, Giovana [1] ; Mennitti, Lais Vales [1] ; Ribeiro, Daniel Araki [2] ; Cardoso, Caroline Margonato [1] ; de Rosso, Veridiana Vera [2] ; Oyama, Lila Missae [3] ; Pisani, Luciana Pellegrini [2, 4]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-11015020 Santos - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Santos - Brazil
[3] Univ Fed Sao Paulo, Dept Fisiol, BR-04023062 Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Lab Nutr & Fisiol Endocrina LaNFE, Dept Biociencias, Inst Saude & Soc, Rua Silva Jardim 136, BR-11015020 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Molecules; v. 24, n. 9 MAY 1 2019.
Citações Web of Science: 0
Resumo

Jucara berry is a potential inflammatory modulator, rich in dietary fiber, fatty acids, and anthocyanins. Considering this, we evaluated the high-fat diet (HFD) intake supplemented with different doses of freeze-dried jucara pulp on the TLR4 pathway. Twenty-seven male Wistar rats with ad libitum access to food and water were divided into four experimental groups: control standard chow group (C); high-fat diet control group (HFC); high-fat diet jucara 0.25% group (HFJ0.25%); and high-fat diet jucara 0.5% group (HFJ0.5%). The inflammatory parameters were analyzed by ELISA and Western blotting in liver and retroperitoneal adipose tissue (RET). The HFJ0.25% group had the energy intake, aspartate transaminase (AST) levels, and liver triacylglycerol accumulation reduced; also, the tumor necrosis factor (TNF-) and TNF receptor-associated factor 6 (TRAF6) expression in RET were reduced. However, there were no changes in other protein expressions in liver and adipose tissue. Adiposity and pNFBp50 had a positive correlation in HFC and HFJ0.5%, but not in the C group and HFJ0.25%. The necrosis hepatic score did not change with treatment; however, the serum (AST) levels and the hepatic triacylglycerol were increased in HFC and HFJ0.5%. These results demonstrated that one week of HFD intake triggered pro-inflammatory mechanisms and liver injury. Additionally, 0.25% jucara prevented inflammatory pathway activation, body weight gain, and liver damage (AU)

Processo FAPESP: 18/23623-7 - Efeito da suplementação de ácido oléico e cianidinas em macrófagos na modulação de processos inflamatórios.
Beneficiário:Aline Boveto Santamarina
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 15/13875-0 - EFEITO DA SUPLEMENTAÇÃO DO FRUTO DA PALMEIRA JUÇARA (Euterpe edulis Mart.) NAS MODIFICAÇÕES EPIGENÉTICAS E ESTADO INFLAMATÓRIO EM MONÓCITOS DE ADULTOS OBESOS
Beneficiário:Aline Boveto Santamarina
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/14133-0 - Mecanismos intracelulares envolvidos com o processo inflamatório em indivíduos obesos antes e após a suplementação de polpa de juçara (Euterpe edulis Mart.)
Beneficiário:Luciana Pellegrini Pisani
Linha de fomento: Auxílio à Pesquisa - Regular