Polyphenols-Rich Fruit (Euterpe edulis Mart.) Prevents Peripheral Inflammatory Pathway Activation by the Short-Term High-Fat Diet

Author(s)

Santamarina, Aline Boveto ^[1] ; Jamar, Giovana ^[1] ; Mennitti, Lais Vales ^[1] ; Ribeiro, Daniel Araki ^[2] ; Cardoso, Caroline Margonato ^[1] ; de Rosso, Veridiana Vera ^[2] ; Oyama, Lila Missae ^[3] ; Pisani, Luciana Pellegrini ^{[2, 4]}

Affiliation

^[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-11015020 Santos - Brazil

^[2] Univ Fed Sao Paulo, Dept Biociencias, BR-11015020 Santos - Brazil

^[3] Univ Fed Sao Paulo, Dept Fisiol, BR-04023062 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Lab Nutr & Fisiol Endocrina LaNFE, Dept Biociencias, Inst Saude & Soc, Rua Silva Jardim 136, BR-11015020 Sao Paulo - Brazil

• Document type: Journal article
• Source: Molecules; v. 24, n. 9 MAY 1 2019.
• Web of Science Citations: 0

Abstract

Jucara berry is a potential inflammatory modulator, rich in dietary fiber, fatty acids, and anthocyanins. Considering this, we evaluated the high-fat diet (HFD) intake supplemented with different doses of freeze-dried jucara pulp on the TLR4 pathway. Twenty-seven male Wistar rats with ad libitum access to food and water were divided into four experimental groups: control standard chow group (C); high-fat diet control group (HFC); high-fat diet jucara 0.25% group (HFJ0.25%); and high-fat diet jucara 0.5% group (HFJ0.5%). The inflammatory parameters were analyzed by ELISA and Western blotting in liver and retroperitoneal adipose tissue (RET). The HFJ0.25% group had the energy intake, aspartate transaminase (AST) levels, and liver triacylglycerol accumulation reduced; also, the tumor necrosis factor (TNF-) and TNF receptor-associated factor 6 (TRAF6) expression in RET were reduced. However, there were no changes in other protein expressions in liver and adipose tissue. Adiposity and pNFBp50 had a positive correlation in HFC and HFJ0.5%, but not in the C group and HFJ0.25%. The necrosis hepatic score did not change with treatment; however, the serum (AST) levels and the hepatic triacylglycerol were increased in HFC and HFJ0.5%. These results demonstrated that one week of HFD intake triggered pro-inflammatory mechanisms and liver injury. Additionally, 0.25% jucara prevented inflammatory pathway activation, body weight gain, and liver damage (AU)

• FAPESP's process: 18/23623-7 - The effects of oleic acid and cyanidin supplementation of macrophages on the modulation of inflammatory processes
• Grantee: Aline Boveto Santamarina
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 15/13875-0 - EFFECT OF PALM JUÇARA FRUIT (Euterpe edulis Mart.) SUPPLEMENTATION ON EPIGENETIC MODIFICATIONS AND INFLAMMATORY STATUS IN MONOCYTES OF OBESE ADULTS.
• Grantee: Aline Boveto Santamarina
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/14133-0 - Intracellular mechanisms implicated to inflammatory process in obese subjects before and after supplementation juçara pulp
• Grantee: Luciana Pellegrini Pisani
• Support Opportunities: Regular Research Grants