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Activation of Interleukin-1 Beta in Arterialized Vein Grafts and the Influence of the -511C/T IL-1 beta Gene Polymorphism

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Autor(es):
Miyakawa, Ayumi Aurea [1] ; Bonin, Thaiz Ferraz [1] ; Gastalho Campos, Luciene Cristina [1] ; Girao-Silva, Thais [1] ; Ribeiro-Silva, Joao Carlos [1] ; Oliveira Dallan, Luis Alberto [1] ; Krieger, Jose Eduardo [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Med Sch, Heart Inst InCor, BR-05403000 Sao Paulo, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE; v. 6, n. 2 JUN 2019.
Citações Web of Science: 0
Resumo

The interleukin-1 family is associated with innate immunity and inflammation. The latter has been linked to the genesis of cardiovascular diseases. We, therefore, investigated whether interleukin-1 beta (IL-1 beta) is activated during arterialization of vein grafts. First, we examined the activation of IL-1 beta using the rat arterialized jugular vein serially sampled for up to 90 days. IL-1 beta expression increased 18 times on day 1 in the arterialized rat jugular vein and remained five times above nonarterialized vein levels for up to 90 days. Similarly, IL-1 beta expression increased early (1-5 days) in human vein graft autopsy samples compared with late phases (1-4 years). Activation was also detected in ex vivo arterialized human saphenous veins. Upon stratification of the results, we uncovered a T allele promoter attenuating effect in IL-1 beta activation in response to hemodynamic stress. Altogether, the results show that IL-1 beta is activated during arterialization of vein grafts in rats and humans, and this response is modulated by -511C/T IL-1 beta gene polymorphism. It is tempting to speculate that the activation of IL-1 beta, and consequently local inflammation, modulates early vascular remodeling and that the gene polymorphism may be useful in predicting outcomes or assisting in interventions. (AU)

Processo FAPESP: 17/05829-4 - Avaliação da influência de fibroblastos sobre a maturação e indução de cardiomiócitos com potencial arritmogênico
Beneficiário:Agatha Ribeiro da Silva
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
Beneficiário:José Eduardo Krieger
Linha de fomento: Auxílio à Pesquisa - Temático