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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Activation of Interleukin-1 Beta in Arterialized Vein Grafts and the Influence of the -511C/T IL-1 beta Gene Polymorphism

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Author(s):
Miyakawa, Ayumi Aurea [1] ; Bonin, Thaiz Ferraz [1] ; Gastalho Campos, Luciene Cristina [1] ; Girao-Silva, Thais [1] ; Ribeiro-Silva, Joao Carlos [1] ; Oliveira Dallan, Luis Alberto [1] ; Krieger, Jose Eduardo [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Med Sch, Heart Inst InCor, BR-05403000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE; v. 6, n. 2 JUN 2019.
Web of Science Citations: 0
Abstract

The interleukin-1 family is associated with innate immunity and inflammation. The latter has been linked to the genesis of cardiovascular diseases. We, therefore, investigated whether interleukin-1 beta (IL-1 beta) is activated during arterialization of vein grafts. First, we examined the activation of IL-1 beta using the rat arterialized jugular vein serially sampled for up to 90 days. IL-1 beta expression increased 18 times on day 1 in the arterialized rat jugular vein and remained five times above nonarterialized vein levels for up to 90 days. Similarly, IL-1 beta expression increased early (1-5 days) in human vein graft autopsy samples compared with late phases (1-4 years). Activation was also detected in ex vivo arterialized human saphenous veins. Upon stratification of the results, we uncovered a T allele promoter attenuating effect in IL-1 beta activation in response to hemodynamic stress. Altogether, the results show that IL-1 beta is activated during arterialization of vein grafts in rats and humans, and this response is modulated by -511C/T IL-1 beta gene polymorphism. It is tempting to speculate that the activation of IL-1 beta, and consequently local inflammation, modulates early vascular remodeling and that the gene polymorphism may be useful in predicting outcomes or assisting in interventions. (AU)

FAPESP's process: 17/05829-4 - Evaluation of the influence of fibroblasts on maturation and induction of cardiomyocytes with arrhythmogenic potential
Grantee:Agatha Ribeiro da Silva
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther
Grantee:José Eduardo Krieger
Support Opportunities: Research Projects - Thematic Grants