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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Enteroendocrine Connections in Congenital Isolated GH Deficiency Due to a GHRH Receptor Gene Mutation

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Autor(es):
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Oliveira-Santos, Alecia A. [1] ; Salvatori, Roberto [2] ; Nogueira, Monica C. [3] ; Bueno, Ana C. [3] ; Barros-Oliveira, Cynthia S. [1] ; Leal, Angela C. G. B. [1] ; Marinho, Cindi G. [1] ; Damascena, Nayra P. [1] ; Oliveira, Djane A. [1] ; Melo, Manuela A. [1] ; Oliveira, Carla R. P. [1] ; da Costa, Flavia O. [1] ; dos Santos, Jessica S. S. [1] ; Santos, Paula F. C. [1] ; Campos, Viviane C. [1] ; Santos, Elenilde G. [1] ; Melo, Enaldo V. [1] ; Barbosa, Meirielly L. A. [1] ; Rocha, Ivina E. S. [1] ; de Castro, Margaret [3] ; Aguiar-Oliveira, Manuel H. [1]
Número total de Autores: 21
Afiliação do(s) autor(es):
[1] Univ Fed Sergipe, Div Endocrinol, BR-49060100 Aracaju, Sergipe - Brazil
[2] Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD 21287 - USA
[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; v. 104, n. 7, p. 2777-2784, JUL 2019.
Citações Web of Science: 0
Resumo

Context: GH and IGF-1 are crucial for attainment of normal body size and regulation of food intake, nutrient storage, and insulin sensitivity. Enteroendocrine connections exist between the GH IGF-1 axis and insulin, ghrelin, and glucagon-like peptide 1 (GLP-1). The status of these connections in GH deficiency (GHD) is unknown. Objective: To study the enteroendocrine connections before and after a standard meal test in a homogeneous population of adults with congenital untreated isolated GHD (IGHD) due to a mutation in the GHRH receptor gene. Design: In a cross-sectional study of 20 individuals with IGHD and 20 control subjects, we measured glucose, insulin, ghrelin, and GLP-1 before and 30, 60, 120, and 180 minutes after a standardized test meal. Homeostasis model assessment index of insulin resistance (HOMA-IR) and homeostasis model assessment (HOMA)-6 were calculated. Participants scored feelings of hunger, fullness, and prospective food consumption on a visual analog scale. Main Outcome Measures: Area under the curve (AUC) values of glucose, insulin, ghrelin, GLP-1, hunger, fullness, and prospective food consumption. Results: Fasting HOMA-IR and HOMA-6 were lower in individuals with IGHD than in control subjects (P = 0.002 and P = 0.023, respectively). AUC was higher for hunger (P < 0.0001), glucose (P = 0.0157), ghrelin (P < 0.0001), and GLP-1 (P < 0.0001) and smaller for fullness (P < 0.0001) in individuals with IGHD compared with control subjects. There was no difference in AUC for prospective food consumption or insulin. Conclusions: Untreated IGHD is associated with increased GLP-1 secretion and reduced postprandial ghrelin and hunger attenuation in response to a mixed meal. These enteroendocrine connections can result in a favorable outcome in terms of environmental adaptation and guaranteeing appropriate food intake and can confer metabolic benefits. (AU)

Processo FAPESP: 14/03989-6 - Mecanismos fisiopatológicos e moleculares de tumorigênese: abordagem baseada em plataformas de sequenciamento em escala genômica (NGS - Next-Generation Sequencing)
Beneficiário:Margaret de Castro
Linha de fomento: Auxílio à Pesquisa - Temático