Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Autor(es)

Yamada Yoshikawa, Fabio Seiti ^[1] ; de Lima, Josenilson Feitosa ^[1] ; Sato, Maria Notomi ^[1] ; Leuzzi Ramos, Yasmin Alefe ^[1] ; Aoki, Valeria ^[1] ; Orfali, Raquel Leao ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies LIM 56, BR-01246903 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: TOXINS; v. 11, n. 6 JUN 2019.
• Citações Web of Science: 1

Resumo

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease. (AU)

• Processo FAPESP: 18/23211-0 - Avaliação do perfil dos inflamassomas nas lesões cutâneas de dermatite atópica no adulto
• Beneficiário: Valeria Aoki
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/24161-1 - Caracterização proteômica de exossomas do plasma e de fibroblastos dérmicos na dermatite atópica do adulto
• Beneficiário: Raquel Leão Orfali
• Linha de fomento: Auxílio à Pesquisa - Regular