Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

Author(s)

Yamada Yoshikawa, Fabio Seiti ^[1] ; de Lima, Josenilson Feitosa ^[1] ; Sato, Maria Notomi ^[1] ; Leuzzi Ramos, Yasmin Alefe ^[1] ; Aoki, Valeria ^[1] ; Orfali, Raquel Leao ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies LIM 56, BR-01246903 Sao Paulo, SP - Brazil

• Document type: Review article
• Source: TOXINS; v. 11, n. 6 JUN 2019.
• Web of Science Citations: 1

Abstract

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease. (AU)

• FAPESP's process: 18/23211-0 - Evaluation of inflammasome profile in cutaneous lesions of adults with atopic dermatitis
• Grantee: Valeria Aoki
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/24161-1 - Protemic characterization of exosomes from plasma and dermal fibroblasts in adults with atopic dermatitis
• Grantee: Raquel Leão Orfali
• Support Opportunities: Regular Research Grants