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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obesity as an Inflammatory Agent Can Cause Cellular Changes in Human Milk due to the Actions of the Adipokines Leptin and Adiponectin

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Autor(es):
Morais, Tassiane C. [1, 2] ; de Abreu, Luiz C. [1, 2, 3] ; de Quental, Ocilma B. [2] ; Pessoa, Rafael S. [2, 4] ; Fujimori, Mahmi [2, 4] ; Daboin, Blanca E. G. [2] ; Franca, Eduardo L. [2, 4] ; Honorio-Franca, Adenilda C. [2, 4]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Publ Hlth, Postgrad Program Publ Hlth, BR-01246904 Sao Paulo, SP - Brazil
[2] Ctr Univ SaUde ABC FMABC, Dept Morphol & Physiol, Lab Sci Writing, BR-09060870 Santo Andre, SP - Brazil
[3] Sch Sci Santa Casa Misericordia Vitoria EMESCAM, Postgrad Program Publ Policies & Local Dev, BR-29045402 Vitoria, ES - Brazil
[4] Fed Univ Mato Grosso UFMT, Inst Biol & Hlth Sci, BR-78600000 Mato Grosso, MT - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: CELLS; v. 8, n. 6 JUN 2019.
Citações Web of Science: 2
Resumo

Adiponectin and leptin play roles in the hunger response, and they can induce the inflammatory process as the initial mechanism of the innate immune response. It is possible for alterations in the levels of these adipokines to compromise the functional activity of human colostrum phagocytes. Therefore, the objective of this study is to analyze the effects of adiponectin and leptin on colostrum mononuclear (MN) cells. Colostrum was collected from 80 healthy donors, who were divided into two groups: the control group and the high body mass index (BMI) group. MN cells were used to analyze phagocytosis by flow cytometry, and reactive oxygen species (ROS), intracellular calcium, and apoptosis were assessed by fluorimetry using a microplate reader. Adipokines restored the levels of phagocytosis to the high BMI group (p < 0.05), with a mechanism that is action-dependent on the release of ROS and intracellular calcium. However, adiponectin and leptin simultaneously contributed to better microbicidal activity, thus reflecting an increase in the apoptosis level (p < 0.05) in the high BMI group. Probably, the maintenance of the balance between adiponectin and leptin levels enhances the protection and decreases the indices of neonatal infection in the breastfeeding infants of women with high BMI values. Therefore, policies that support pre-gestational weight control should be encouraged. (AU)

Processo FAPESP: 15/01051-3 - Atividade funcional de células mononucleares do colostro de mães com sobrepeso e obesidade e o papel dos agentes imunomoduladores: adiponectina, leptina e melatonina.
Beneficiário:Tassiane Cristina Morais
Modalidade de apoio: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/19922-0 - Atividade funcional de células mononucleares do colostro de mães com sobrepeso e obesidade e o papel dos agentes imunomoduladores:adiponectina, leptina e melatonina.
Beneficiário:Luiz Carlos de Abreu
Modalidade de apoio: Auxílio à Pesquisa - Regular