Short-term exposure to chrysin promotes proliferative responses in the ventral male prostate and female prostate of adult gerbils

Autor(es)

Campos, Monica S. ^[1] ; Silva, Joao P. A. ^[2] ; Lima, Danilo S. ^[2] ; Regasini, Luis O. ^[3] ; Marques, Mara Rubia ^[2] ; Biancardi, Manoel F. ^[2] ; Taboga, Sebastiao R. ^[1] ; Santos, Fernanda C. A. ^[2]

Afiliação do(s) autor(es)

^[1] State Univ Sao Paulo UNESP, Dept Biol, Lab Microscopy & Microanal, Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Fed Goias, Inst Biol Sci, Dept Histol Embryol & Cell Biol, Lab Microscopy Appl Reprod, BR-74001970 Goiania, Go - Brazil

^[3] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci IBILCE, Dept Chem & Environm Sci, Lab Green & Med Chem, Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Experimental Pathology; v. 100, n. 3, p. 192-201, JUN 2019.
• Citações Web of Science: 0

Resumo

Chrysin (5,7-dihydroxyflavone) is a bioactive compound found in different fruits, vegetables, honey and propolis. This flavone has been suggested for the treatment of reproductive dysfunction, mainly because of its antioxidant and hormonal properties. However, the effects of this polyphenol on the prostate are still poorly understood. The purpose of this study was to evaluate the effects of short-term chrysin exposure on the ventral male and female prostates of adult gerbils. To evaluate the androgenic potential of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin (50 mg/kg/day, orally) or testosterone cypionate (1 mg/kg/week, subcutaneously) for 3, 7 and 21 days. Prostates were dissected for morphological, stereological and immunohistochemical analyses. Serum levels of testosterone and 17 beta-estradiol were measured by ELISA. Serum testosterone levels were not increased by chrysin supplementation in males or females. However, only females treated with chrysin for 21 days showed an increase in estradiol levels. Increased androgen receptor immunoreactivity, higher proliferation rates and glandular hyperplasia were observed in male and female prostates for all chrysin treatment times. Additionally, increased oestrogen receptor alpha immunoreactivity was observed in all chrysin-treated females. Although chrysin and testosterone promoted similar morphological changes in the gerbil prostate, chrysin supplementation was less deleterious to prostate health, since it resulted in lower incidence of hyperplasia and an absence of neoplastic foci. (AU)

• Processo FAPESP: 14/18330-0 - Preparação e avaliação biológica de híbridos curcumina-cinamaldeído como inibidores da divisão celular bacteriana
• Beneficiário: Luis Octávio Regasini
• Modalidade de apoio: Auxílio à Pesquisa - Regular