Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners

Autor(es):Mostrar menos -

Vaisberg, Mauro ^[1] ; Paixao, Vitoria ^[1] ; Almeida, Ewin B. ^[1] ; Santos, Juliana M. B. ^[1] ; Foster, Roberta ^[1] ; Rossi, Marcelo ^[1] ; Pithon-Curi, Tania C. ^[2] ; Gorjao, Renata ^[2] ; Momesso, Cesar M. ^[2] ; Andrade, Marilia S. ^[3] ; Araujo, Jose R. ^[4] ; Garcia, Mauricio C. ^[5] ; Cohen, Moises ^[5] ; Perez, Elizabeth C. ^[6] ; Santos-Dias, Alana ^[7] ; Vieira, Rodolfo P. ^{[8, 9, 10, 11]} ; Bachi, Andre L. L. ^{[1, 8]}

Afiliação do(s) autor(es):Mostrar menos -

^[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, BR-04039032 Sao Paulo, SP - Brazil

^[2] Univ Cruzeiro Sul, Inst Phys Act Sci & Sport, BR-01506000 Sao Paulo, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Dept Physiol, BR-04023062 Sao Paulo, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Morphol, BR-04023900 Sao Paulo, SP - Brazil

^[5] Fed Univ Sao Paulo UNIFESP, Dept Orthopaed & Traumatol, BR-04024002 Sao Paulo, SP - Brazil

^[6] Paulista Univ UNIP, Environm & Expt Pathol, BR-04043200 Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Childrens Inst, Fac Med, BR-05403000 Sao Paulo, SP - Brazil

^[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Jose Dos Campos, SP - Brazil

^[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-08230030 Sao Paulo, SP - Brazil

^[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, BR-11060001 Santos, SP - Brazil

^[11] Anhembi Morumbi Univ, Sch Med, BR-12230002 Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRIENTS; v. 11, n. 7 JUL 2019.
• Citações Web of Science: 2

Resumo

Background. Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway immune/inflammatory responses before and after a marathon. Methods. Forty-two male marathon runners ingested a fermented milk containing 40 billion of LcS/day (LcS group, n = 20) or placebo (unfermented milk, n = 22) during 30 days pre-marathon. Immune/inflammatory parameters in nasal mucosa and serum, as well as concentrations of secretory IgA (SIgA) and antimicrobial peptides in saliva, were evaluated before and after fermented milk ingestion, immediately, 72 h, and 14 d post-marathon. Results. Higher proinflammatory cytokine levels in serum and nasal mucosa, and also lower salivary levels of SIgA and antimicrobial peptides, were found immediately post-marathon in the placebo group compared to other time points and to LcS group. In opposite, higher anti-inflammatory levels and reduced neutrophil infiltration on nasal mucosa were found in the LcS group compared to other time points and to the placebo group. Conclusion. For the first time, it is shown that LcS is able to modulate the systemic and airways immune responses post-marathon. (AU)

• Processo FAPESP: 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos
• Beneficiário: Rodolfo de Paula Vieira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/04845-3 - INFLUÊNCIA DA INGESTÃO DIÁRIA DO Lactobacillus casei Shirota (LcS) NA RESPOSTA IMUNE SISTÊMICA E DAS VIAS AÉREAS SUPERIORES DE MARATONISTAS AMADORES QUE APRESENTEM MOLÉSTIAS DE VIAS AÉREAS SUPERIORES
• Beneficiário: André Luis Lacerda Bachi
• Modalidade de apoio: Auxílio à Pesquisa - Regular